Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Extracellular vesicles derived from mesenchymal stem cells (MSC) in regenerative medicine: applications in skin wound healing

A Casado-Díaz, JM Quesada-Gómez… - … in Bioengineering and …, 2020 - frontiersin.org
The cells secrete extracellular vesicles (EV) that may have an endosomal origin, or from
evaginations of the plasma membrane. The former are usually called exosomes, with sizes …

Therapeutic properties of mesenchymal stromal/stem cells: the need of cell priming for cell-free therapies in regenerative medicine

V Miceli, M Bulati, G Iannolo, G Zito, A Gallo… - International Journal of …, 2021 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …

Characteristics and therapeutic potential of human amnion-derived stem cells

QW Liu, QM Huang, HY Wu, GSL Zuo, HC Gu… - International journal of …, 2021 - mdpi.com
Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs)
and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and …

Specificity of 3D MSC spheroids microenvironment: impact on MSC behavior and properties

A Jauković, D Abadjieva, D Trivanović… - Stem cell reviews and …, 2020 - Springer
Mesenchymal stem cells (MSC) have been considered the promising candidates for the
regenerative and personalized medicine due to their self-renewal potential, multilineage …

Immunosuppressive effects of mesenchymal stem cells-derived exosomes

X Qian, N An, Y Ren, C Yang, X Zhang, L Li - Stem cell reviews and reports, 2021 - Springer
Mesenchymal stem cells (MSCs) have become important seed cells in therapy because of
their immunosuppressive function and anti-inflammatory effects. MSCs exert …

Production and utility of extracellular vesicles with 3D culture methods

M Casajuana Ester, RM Day - Pharmaceutics, 2023 - mdpi.com
In recent years, extracellular vesicles (EVs) have emerged as promising biomarkers, cell-
free therapeutic agents, and drug delivery carriers. Despite their great clinical potential, poor …

Towards the standardization of mesenchymal stem cell secretome-derived product manufacturing for tissue regeneration

B Chouaib, M Haack-Sørensen, F Chaubron… - International Journal of …, 2023 - mdpi.com
Mesenchymal stem cell secretome or conditioned medium (MSC-CM) is a combination of
biomolecules and growth factors in cell culture growth medium, secreted by mesenchymal …

The immunomodulatory properties of the human amnion-derived mesenchymal stromal/stem cells are induced by INF-γ produced by activated lymphomonocytes and …

M Bulati, V Miceli, A Gallo, G Amico… - Frontiers in …, 2020 - frontiersin.org
Human mesenchymal stromal/stem cells (MSCs), being immunoprivileged and having
immunomodulatory ability, represent a promising tool to be applied in the field of …

Cell culture‐derived extracellular vesicles: Considerations for reporting cell culturing parameters

F Shekari, FJ Alibhai, H Baharvand… - Journal of …, 2023 - Wiley Online Library
Cell culture‐conditioned medium (CCM) is a valuable source of extracellular vesicles (EVs)
for basic scientific, therapeutic and diagnostic applications. Cell culturing parameters affect …