Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Following the identification of cyclin-dependent kinases in the 1980s, kinases were hailed
as the directors of mitosis. Although the action of kinases must necessarily be reversible …

Correct chromosome segregation is essential in order to prevent aneuploidy. To segregate
sister chromatids equally to daughter cells, the sisters must attach to microtubules …

Cell size checkpoints ensure that passage through G1 and mitosis occurs only when
sufficient growth has occurred. The mechanisms by which these checkpoints work are …

Understanding how cellular functions emerge from the underlying molecular mechanisms is
a key challenge in biology. This will require computational models, whose predictive power …

The spindle position checkpoint (SPOC) is an essential surveillance mechanism that allows
mitotic exit only when the spindle is correctly oriented along the cell axis. Key SPOC …

In order to preserve genome integrity and their ploidy, cells must ensure that the duplicated
genome has been faithfully replicated and evenly distributed before they complete their …

Abstract Protein phosphatase 2A (PP2A) is a tumor suppressor whose function is lost in
many cancers. An emerging, though counterintuitive, therapeutic approach is inhibition of …

Every cell division in budding yeast is inherently asymmetric and counts on the correct
positioning of the mitotic spindle along the mother-daughter polarity axis for faithful …

Budding yeast asymmetric cell division relies upon the precise coordination of spindle
orientation and cell cycle progression. The spindle position checkpoint (SPOC) is a …