Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

As single-cell RNA sequencing (scRNA-seq) has emerged as a great tool for studying
cellular heterogeneity within the past decade, the number of available scRNA-seq datasets …

Non-small-cell lung cancer (NSCLC) is a heterogeneous disease, and therapeutic
management has advanced to identify various critical oncogenic mutations that promote …

Super-resolution microscopy has been recently applied to understand the 3D topology of
chromatin at an intermediated genomic scale (kilobases to a few megabases), as this …

Photoreceptor degeneration caused by genetic defects leads to retinitis pigmentosa, a rare
disease typically diagnosed in adolescents and young adults. In most cases, rod loss occurs …

Since the discovery of the first microRNA (miR), almost three decades ago, the roles played
by miRs under normal and diseased settings have been widely investigated. miRs are found …

Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD)
development is needed to devise intervention strategies. Here we studied 246,102 single …

Arginine, glutamine, and the branched chain amino acids (BCAAs) are a focus of increased
interest in the field of oncology due to their importance in the metabolic reprogramming of …

Lung cancer is the leading cause of cancer deaths. Lethal pulmonary adenocarcinomas
(ADC) present with frequent mutations in the EGFR. Genetically engineered murine models …

Single-cell RNA-sequencing is an invaluable research tool that allows for the investigation
of gene expression in heterogeneous cancer cell populations in ways that bulk RNA-seq …