New horizons for precision medicine in biliary tract cancers

JW Valle, A Lamarca, L Goyal, J Barriuso, AX Zhu - Cancer discovery, 2017 - AACR
Biliary tract cancers (BTC), including cholangiocarcinoma and gallbladder cancer, are poor-
prognosis and low-incidence cancers, although the incidence of intrahepatic …

Current and emerging therapies for advanced biliary tract cancers

AE Kam, A Masood, RT Shroff - The lancet Gastroenterology & …, 2021 - thelancet.com
Biliary tract cancers (cholangiocarcinomas and gallbladder cancers) are increasing in
incidence and have a poor prognosis. Most patients present with advanced disease, for …

Overview of current targeted therapy in gallbladder cancer

X Song, Y Hu, Y Li, R Shao, F Liu, Y Liu - Signal Transduction and …, 2020 - nature.com
Gallbladder cancer (GBC) is rare, but is the most malignant type of biliary tract tumor.
Unfortunately, only a small population of cancer patients is acceptable for the surgical …

Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes

D Sia, Y Hoshida, A Villanueva, S Roayaie, J Ferrer… - Gastroenterology, 2013 - Elsevier
BACKGROUND & AIMS: Cholangiocarcinoma, the second most common liver cancer, can
be classified as intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma …

Pathogenesis of cholangiocarcinoma

PM Rodrigues, P Olaizola, NA Paiva… - Annual Review of …, 2021 - annualreviews.org
Cholangiocarcinoma (CCA) encompasses a group of malignancies that can arise at any
point in the biliary tree. Although considered a rare cancer, the incidence of CCA is …

Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma

NF Esnaola, JE Meyer, A Karachristos, JL Maranki… - Cancer, 2016 - Wiley Online Library
Cholangiocarcinomas are rare biliary tract tumors that are often challenging to diagnose and
treat. Cholangiocarcinomas are generally categorized as intrahepatic or extrahepatic …

Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors

JB Andersen, B Spee, BR Blechacz, I Avital, M Komuta… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Cholangiocarcinoma is a heterogeneous disease with a poor
outcome that accounts for 5%− 10% of primary liver cancers. We characterized its genomic …

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial

JW Valle, H Wasan, A Lopes, AC Backen… - The Lancet …, 2015 - thelancet.com
Background Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for
patients with advanced biliary tract cancer; expression of VEGF and its receptors is …

Biliary tract cancer: epidemiology, radiotherapy, and molecular profiling

JA Bridgewater, KA Goodman, A Kalyan… - American Society of …, 2016 - ascopubs.org
Biliary tract cancer, or cholangiocarcinoma, arises from the biliary epithelium of the small
ducts in the periphery of the liver (intrahepatic) and the main ducts of the hilum …

[PDF][PDF] Lusutrombopag for the treatment of thrombocytopenia in patients with chronic liver disease undergoing invasive procedures (L‐PLUS 2)

M Peck‐Radosavljevic, K Simon, A Iacobellis… - …, 2019 - Wiley Online Library
Thrombocytopenia may be associated with increased bleeding risk impacting timing and
outcome of invasive procedures in patients with chronic liver disease (CLD) …