Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …

Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

The senescence programme is implicated in diverse biological processes, including
embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing. Although in vivo …

Sequential progression from chronic liver disease to fibrosis and to cirrhosis culminates in
neoplasia in hepatocellular carcinoma (HCC). The preneoplastic setting of the cirrhotic …

Cellular senescence is a stable cell cycle arrest state that can be triggered by a wide range
of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is …

Background Airway remodeling is a repair process that occurs after injury resulting in
increased airway hyper-responsiveness in asthma. Thymic stromal lymphopoietin (TSLP), a …

Metabolic associated fatty liver disease (MAFLD) is a significant risk factor for the
development of hepatocellular carcinoma (HCC). Hepatic stellate cells (HSCs), as key …

Maintenance of health involves a synchronized network of catabolic and anabolic signals
among organs/tissues/cells that requires differential bioenergetics from mitochondria and …

To detect the effects of tumor necrosis factor‐like weak inducer of apoptosis (TWEAK) on
SIRT1 expression and p53 deacetylation, involving cell senescence, in activated human …