Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …

Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

Intracellular reduction–oxidation (redox) homeostasis, mediated mainly by reactive oxygen
species (ROS), plays a significant role in physiological function maintenance and regulation …

That cancer cells show patterns of metabolism different from normal cells has been known
for over 50 years. Yet, it is only in the past decade or so that an appreciation of the benefits …

Mycotoxins are highly diverse secondary metabolites produced in nature by a wide variety of
fungi. Mycotoxins cause animal feed and food contamination, resulting in mycotoxicosis. T-2 …

The mitochondrion is vital for many metabolic pathways in the cell, contributing all or
important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the …

Background The molecular drivers of early sporadic Parkinson's disease (PD) remain
unclear, and the presence of widespread end stage pathology in late disease masks the …

ATP is required for mammalian cells to remain viable and to perform genetically
programmed functions. Maintenance of the ΔG′ ATP hydrolysis of− 56 kJ/mole is the …

We report that the mitochondrial chaperone TRAP1, which is induced in most tumor types, is
required for neoplastic growth and confers transforming potential to noncancerous cells …