[HTML][HTML] Detection of viral infections by innate immunity
Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …
innate immune system as they detect conserved viral pathogen-associated molecular …
[HTML][HTML] Dengue hemorrhagic fever–A systemic literature review of current perspectives on pathogenesis, prevention and control
WH Wang, AN Urbina, MR Chang… - Journal of Microbiology …, 2020 - Elsevier
Background Dengue is an arboviral disease caused by dengue virus. Symptomatic dengue
infection causes a wide range of clinical manifestations, from mild dengue fever (DF) to …
infection causes a wide range of clinical manifestations, from mild dengue fever (DF) to …
Toll-like receptor 4 in acute viral infection: Too much of a good thing
Although a well-regulated inflammatory response is a vital defense mechanism against viral
infection, too much inflammation can be detrimental. Excessive inflammatory responses …
infection, too much inflammation can be detrimental. Excessive inflammatory responses …
A broadly protective antibody that targets the flavivirus NS1 protein
N Modhiran, H Song, L Liu, C Bletchly, L Brillault… - Science, 2021 - science.org
There are no approved flaviviral therapies and the development of vaccines against
flaviruses has the potential of being undermined by antibody-dependent enhancement …
flaviruses has the potential of being undermined by antibody-dependent enhancement …
Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage
Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can
cause a range of diseases from self-limiting dengue fever to life-threatening dengue …
cause a range of diseases from self-limiting dengue fever to life-threatening dengue …
The good, the bad, and the shocking: the multiple roles of dengue virus nonstructural protein 1 in protection and pathogenesis
DR Glasner, H Puerta-Guardo, PR Beatty… - Annual review of …, 2018 - annualreviews.org
Dengue virus (DENV) is the most prevalent medically important mosquito-borne virus in the
world. Upon DENV infection of a host cell, DENV nonstructural protein 1 (NS1) can be found …
world. Upon DENV infection of a host cell, DENV nonstructural protein 1 (NS1) can be found …
Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate
Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection.
DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever …
DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever …
MicroRNA-155 and antiviral immune responses
A Jafarzadeh, A Naseri, L Shojaie, M Nemati… - International …, 2021 - Elsevier
The microRNA, miR-155 regulates both adaptive and innate immune responses. In viral
infections, miR-155 can affect both innate immunity (interferon response, natural killer cell …
infections, miR-155 can affect both innate immunity (interferon response, natural killer cell …
Flavivirus NS1 and its potential in vaccine development
KL Carpio, ADT Barrett - Vaccines, 2021 - mdpi.com
The Flavivirus genus contains many important human pathogens, including dengue,
Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) …
Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) …
Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins
The dengue virus nonstructural protein 1 (NS1) is a secreted virulence factor that modulates
complement, activates immune cells and alters endothelial barriers. The molecular basis of …
complement, activates immune cells and alters endothelial barriers. The molecular basis of …