[HTML][HTML] Detection of viral infections by innate immunity

M Carty, C Guy, AG Bowie - Biochemical pharmacology, 2021 - Elsevier
Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …

[HTML][HTML] Dengue hemorrhagic fever–A systemic literature review of current perspectives on pathogenesis, prevention and control

WH Wang, AN Urbina, MR Chang… - Journal of Microbiology …, 2020 - Elsevier
Background Dengue is an arboviral disease caused by dengue virus. Symptomatic dengue
infection causes a wide range of clinical manifestations, from mild dengue fever (DF) to …

Toll-like receptor 4 in acute viral infection: Too much of a good thing

J Olejnik, AJ Hume, E Mühlberger - PLoS pathogens, 2018 - journals.plos.org
Although a well-regulated inflammatory response is a vital defense mechanism against viral
infection, too much inflammation can be detrimental. Excessive inflammatory responses …

A broadly protective antibody that targets the flavivirus NS1 protein

N Modhiran, H Song, L Liu, C Bletchly, L Brillault… - Science, 2021 - science.org
There are no approved flaviviral therapies and the development of vaccines against
flaviruses has the potential of being undermined by antibody-dependent enhancement …

Dengue virus nonstructural protein 1 activates platelets via Toll-like receptor 4, leading to thrombocytopenia and hemorrhage

CH Chao, WC Wu, YC Lai, PJ Tsai, GC Perng… - PLoS …, 2019 - journals.plos.org
Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can
cause a range of diseases from self-limiting dengue fever to life-threatening dengue …

The good, the bad, and the shocking: the multiple roles of dengue virus nonstructural protein 1 in protection and pathogenesis

DR Glasner, H Puerta-Guardo, PR Beatty… - Annual review of …, 2018 - annualreviews.org
Dengue virus (DENV) is the most prevalent medically important mosquito-borne virus in the
world. Upon DENV infection of a host cell, DENV nonstructural protein 1 (NS1) can be found …

Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate

HR Chen, YC Lai, TM Yeh - Journal of biomedical science, 2018 - Springer
Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection.
DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever …

MicroRNA-155 and antiviral immune responses

A Jafarzadeh, A Naseri, L Shojaie, M Nemati… - International …, 2021 - Elsevier
The microRNA, miR-155 regulates both adaptive and innate immune responses. In viral
infections, miR-155 can affect both innate immunity (interferon response, natural killer cell …

Flavivirus NS1 and its potential in vaccine development

KL Carpio, ADT Barrett - Vaccines, 2021 - mdpi.com
The Flavivirus genus contains many important human pathogens, including dengue,
Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) …

Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins

S Benfrid, KH Park, M Dellarole, JE Voss, C Tamietti… - EMBO …, 2022 - embopress.org
The dengue virus nonstructural protein 1 (NS1) is a secreted virulence factor that modulates
complement, activates immune cells and alters endothelial barriers. The molecular basis of …