Lipid droplets in chordates are decorated by two or more members of the perilipin family of
lipid droplet surface proteins. The perilipins sequester lipids by protecting lipid droplets from …

Abstract The Peroxisome Proliferator Activated Receptor alpha (PPARα) is a transcription
factor that plays a major role in metabolic regulation. This review addresses the functional …

Physical endurance and energy conservation are essential for survival in the wild. However,
it remains unknown whether and how meal timing regulates physical endurance and muscle …

Cytoplasmic lipid droplets are important organelles in nearly every eukaryotic and some
prokaryotic cells. Storing and providing energy is their main function, but they do not work in …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …

Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle
is associated with obesity and promotes the development of type 2 diabetes. In skeletal …

Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the
last two decades there has been a dramatic growth in our understanding of LD biology and …

Lipolysis is the biochemical pathway responsible for the catabolism of triacylglycerol (TAG)
stored in cellular lipid droplets. The hydrolytic cleavage of TAG generates non-esterified fatty …

Maintaining cellular lipid homeostasis is crucial to oxidative tissues, and it becomes
compromised in obesity. Lipid droplets (LD) play a central role in lipid homeostasis by …