The drug-tolerant persister (DTP) state enables cancer cells to evade cytotoxic stress from
anticancer therapy. However, the mechanisms governing DTP generation remain poorly …

In the rapidly moving proteomics field, a diverse patchwork of data analysis pipelines and
algorithms for data normalization and differential expression analysis is used by the …

Lysine acetylation is a conserved regulatory posttranslational protein modification that is
performed by lysine acetyltransferases (KATs). By catalyzing the transfer of acetyl groups to …

Mass spectrometry (MS)-based proteomics has become the most powerful approach to
study the proteome of given biological and clinical samples. Advancements in sample …

Background The analysis of mass spectrometry-based quantitative proteomics data can be
challenging given the variety of established analysis platforms, the differences in reporting …

Simple Summary TP53 is the most frequently mutated gene in many cancers, but it has
failed to be a very effective target for treatment to date. To overcome this, we have examined …

Single‐cell MALDI mass spectrometry imaging (MSI) of lipids and metabolites> 200 Da has
recently come to the forefront of biomedical research and chemical biology. However, cell …

Mass spectrometry in multiple reaction monitoring (MRM) mode is a powerful technique that
can provide highly selective, multiplexed, and reproducible quantification of peptides …

Background The importance of parental diet in relation to eventual offspring health is
increasing in prominence due to the increased frequency of parents of reproductive age …

Palbociclib is a specific CDK4/6 inhibitor that has been widely applied in multiple types of
tumors. Different from cytotoxic drugs, the anticancer mechanism of palbociclib mainly …