Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches

M Hashemi, N Nadafzadeh, MH Imani, R Rajabi… - Cell Communication and …, 2023 - Springer
Autophagy is an evolutionarily conserved process that plays a role in regulating
homeostasis under physiological conditions. However, dysregulation of autophagy is …

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 …

Q Li, Y Ni, L Zhang, R Jiang, J Xu, H Yang… - Signal transduction and …, 2021 - nature.com
Abstract N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …

Autophagy-related microRNAs: possible regulatory roles and therapeutic potential in and gastrointestinal cancers

MH Pourhanifeh, M Vosough… - Pharmacological …, 2020 - Elsevier
Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are
associated with severe morbidity and mortality around the world. It is well recognized that …

[HTML][HTML] lncRNA SNHG11 promotes gastric cancer progression by activating the Wnt/β-catenin pathway and oncogenic autophagy

Q Wu, J Ma, J Wei, W Meng, Y Wang, M Shi - Molecular Therapy, 2021 - cell.com
Long non-coding RNAs (lncRNAs) are under active investigation in the development of
cancers, including gastric cancer (GC). Oncogenic autophagy is required for cancer cell …

Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation

H Sang, W Zhang, L Peng, S Wei, X Zhu, K Huang… - Cell Death & …, 2022 - nature.com
Circular RNAs (circRNAs) play a vital role in the occurrence and development of tumors,
including gastric cancer (GC). However, there are still many circRNAs related to GC whose …

miR‐155‐5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction

Y Hong, H He, G Jiang, H Zhang, W Tao, Y Ding… - Aging cell, 2020 - Wiley Online Library
Aging impairs the functions of human mesenchymal stem cells (MSCs), thereby severely
reducing their beneficial effects on myocardial infarction (MI). MicroRNAs (miRNAs) play …

Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2‐mediated autophagy

L Fang, J Lv, Z Xuan, B Li, Z Li, Z He… - Clinical and …, 2022 - Wiley Online Library
Background Chemotherapy can significantly improve the disease‐free survival and overall
survival of patients with advanced gastric cancer (GC). 5‐fluorouracil (5‐FU) is frequently …

[HTML][HTML] The emerging roles of autophagy-related microRNAs in cancer

C Shan, X Chen, H Cai, X Hao, J Li… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Autophagy is a conserved catabolic process involving the degradation and recycling of
damaged biomacromolecules or organelles through lysosomal-dependent pathways and …

MicroRNAs play an essential role in autophagy regulation in various disease phenotypes

Y Zhao, Z Wang, W Zhang, L Zhang - Biofactors, 2019 - Wiley Online Library
Autophagy is a highly conserved catabolic process and fundamental biological process in
eukaryotic cells. It recycles intracellular components to provide nutrients during starvation …

miR-210-5p promotes epithelial–mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells

W Liu, D Jiang, F Gong, Y Huang, Y Luo, Y Rong… - Cell death & …, 2020 - nature.com
Osteosarcoma (OS) is a malignant bone tumor which occurs mainly in adolescents with
frequent pulmonary metastasis and a high mortality rate. Accumulating evidence has …