Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch
GN Naumov, LA Akslen, J Folkman - Cell cycle, 2006 - Taylor & Francis
Tumor progression depends on sequential events, including a switch to the angiogenic
phenotype (ie initial recruitment of blood vessels). Failure of a microscopic tumor to …
phenotype (ie initial recruitment of blood vessels). Failure of a microscopic tumor to …
Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis
Breast cancer remains a leading cause of morbidity and mortality in women, mainly due to
the propensity of primary breast tumors to metastasize to regional and distant sites …
the propensity of primary breast tumors to metastasize to regional and distant sites …
In vivo MRI of cancer cell fate at the single‐cell level in a mouse model of breast cancer metastasis to the brain
Metastasis (the spread of cancer from a primary tumor to secondary organs) is responsible
for most cancer deaths. The ability to follow the fate of a population of tumor cells over time …
for most cancer deaths. The ability to follow the fate of a population of tumor cells over time …
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
M Singh, A Lima, R Molina, P Hamilton… - Nature …, 2010 - nature.com
The low rate of approval of novel anti-cancer agents underscores the need for better
preclinical models of therapeutic response as neither xenografts nor early-generation …
preclinical models of therapeutic response as neither xenografts nor early-generation …
Specific growth rate versus doubling time for quantitative characterization of tumor growth rate
E Mehrara, E Forssell-Aronsson, H Ahlman… - Cancer research, 2007 - AACR
Doubling time (DT) is widely used for quantification of tumor growth rate. DT is usually
determined from two volume estimations with measurement time intervals comparable with …
determined from two volume estimations with measurement time intervals comparable with …
MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
H Jin, R Yang, Z Zheng, M Romero, J Ross… - Cancer research, 2008 - AACR
The hepatocyte growth factor (HGF) and its receptor, c-Met, have been implicated in driving
proliferation, invasion, and poor prognosis in pancreatic cancer. Here, we investigated the …
proliferation, invasion, and poor prognosis in pancreatic cancer. Here, we investigated the …
Ultrasound imaging of apoptosis in tumor response: novel preclinical monitoring of photodynamic therapy effects
B Banihashemi, R Vlad, B Debeljevic, A Giles… - Cancer research, 2008 - AACR
High-frequency ultrasound is a novel method to detect apoptotic cell death based on
changes in cell morphology that cause alterations in the viscoelastic and, consequently, the …
changes in cell morphology that cause alterations in the viscoelastic and, consequently, the …
Contrast agents for preclinical targeted X-ray imaging
Micro-computed tomography (micro-CT) is an X-ray based instrument that it is specifically
designed for biomedical research at a preclinical stage for live imaging of small animals …
designed for biomedical research at a preclinical stage for live imaging of small animals …
Non‐invasive molecular imaging for preclinical cancer therapeutic development
AC O'farrell, SD Shnyder, G Marston… - British journal of …, 2013 - Wiley Online Library
Molecular and non‐invasive imaging are rapidly emerging fields in preclinical cancer drug
discovery. This is driven by the need to develop more efficacious and safer treatments, the …
discovery. This is driven by the need to develop more efficacious and safer treatments, the …
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment
VT Phan, X Wu, JH Cheng, RX Sheng… - Proceedings of the …, 2013 - National Acad Sciences
Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b+ Gr1+
myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models …
myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models …