Tumor progression depends on sequential events, including a switch to the angiogenic
phenotype (ie initial recruitment of blood vessels). Failure of a microscopic tumor to …

Breast cancer remains a leading cause of morbidity and mortality in women, mainly due to
the propensity of primary breast tumors to metastasize to regional and distant sites …

Metastasis (the spread of cancer from a primary tumor to secondary organs) is responsible
for most cancer deaths. The ability to follow the fate of a population of tumor cells over time …

The low rate of approval of novel anti-cancer agents underscores the need for better
preclinical models of therapeutic response as neither xenografts nor early-generation …

Doubling time (DT) is widely used for quantification of tumor growth rate. DT is usually
determined from two volume estimations with measurement time intervals comparable with …

The hepatocyte growth factor (HGF) and its receptor, c-Met, have been implicated in driving
proliferation, invasion, and poor prognosis in pancreatic cancer. Here, we investigated the …

High-frequency ultrasound is a novel method to detect apoptotic cell death based on
changes in cell morphology that cause alterations in the viscoelastic and, consequently, the …

Micro-computed tomography (micro-CT) is an X-ray based instrument that it is specifically
designed for biomedical research at a preclinical stage for live imaging of small animals …

Molecular and non‐invasive imaging are rapidly emerging fields in preclinical cancer drug
discovery. This is driven by the need to develop more efficacious and safer treatments, the …

Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b+ Gr1+
myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models …