Damage to organs by trauma, infection, diseases, congenital defects, aging, and other
injuries causes organ malfunction and is life-threatening under serious conditions. Some of …

Cell signalling engenders cells with the capability to receive and process information from
the intracellular and extracellular environments, trigger and execute biological responses …

The cell stress‐responsive transcription factor p53 influences the expression of its target
genes and subsequent cellular responses based in part on its dynamics (changes in level …

Experimental data can broadly be divided in discrete or continuous data. Continuous data
are obtained from measurements that are performed as a function of another quantitative …

Combining single‐cell measurements of ERK activity dynamics with perturbations provides
insights into the MAPK network topology. We built circuits consisting of an optogenetic …

Single-cell level analysis of various cellular behaviors has been aided by recent
developments in microfluidic technology. Polydimethylsiloxane (PDMS)-based microfluidic …

Kinases play key roles in signaling networks that are activated by G-protein-coupled
receptors (GPCRs). Kinase activities are generally inferred from cell lysates, hiding cell-to …

Increased MAPK signaling is a hallmark of various cancers and is a central regulator of cell
survival. Direct ERK1/2 inhibition is considered a promising approach to avoid ERK1/2 …

The proto-oncogenic epidermal growth factor (EGF) receptor (EGFR) is a tyrosine kinase
whose sensitivity and response to growth factor signals that vary over time and space …

How hematopoietic stem cells (HSCs) integrate signals from their environment to make fate
decisions remains incompletely understood. Current knowledge is based on either averages …