Circulating concentrations of the pleiotropic cytokine interleukin-6 (IL-6) are known to be
increased in pro-inflammatory critical care syndromes, such as sepsis and acute respiratory …

Abstract α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …

Rationale: Coronavirus disease (COVID-19) is a global threat to health. Its inflammatory
characteristics are incompletely understood. Objectives: To define the cytokine profile of …

Neutrophils are the predominant immune cells in human blood possessing heterogeneity,
plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed …

Mast cells are tissue-inhabiting cells that play an important role in inflammatory diseases of
the airway tract. Mast cells arise in the bone marrow as progenitor cells and complete their …

Alpha-1 antitrypsin (AAT) is the canonical serine protease inhibitor of neutrophil-derived
proteases and can modulate innate immune mechanisms through its anti-inflammatory …

Serpins are a broadly distributed superfamily of protease inhibitors that are present in all
kingdoms of life. The acronym, serpin, is derived from their function as potent ser ine p …

Alpha-1 antitrypsin deficiency (AATD) is characterized by low levels of circulating alpha-1
antitrypsin and an increased risk for emphysema, liver disease, and panniculitis. The …

Rationale: The ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is associated with
chronic obstructive pulmonary disease (COPD), even among never-smokers. The SZ …

Abstract Alpha-1 antitrypsin (A1AT) is a protease inhibitor in the serum. Its primary function is
to inhibit the activity of a series of proteases, including proteinase 3, neutrophil elastase …