What is the pipeline for future medications for obesity?

E Melson, U Ashraf, D Papamargaritis… - International Journal of …, 2024 - nature.com
Obesity is a chronic disease associated with increased risk of obesity-related complications
and mortality. Our better understanding of the weight regulation mechanisms and the role of …

Mechanisms of weight loss after obesity surgery

E Akalestou, AD Miras, GA Rutter… - Endocrine …, 2022 - academic.oup.com
Obesity surgery remains the most effective treatment for obesity and its complications.
Weight loss was initially attributed to decreased energy absorption from the gut but has …

Safety and efficacy of liraglutide, 3.0 mg, once daily vs placebo in patients with poor weight loss following metabolic surgery: the BARI-OPTIMISE randomized clinical …

J Mok, MO Adeleke, A Brown, CG Magee… - JAMA …, 2023 - jamanetwork.com
Importance Metabolic surgery leads to weight loss and improved health, but these outcomes
are highly variable. Poor weight loss is associated with lower circulating levels of glucagon …

Efficacy of the glucagon-like peptide-1 receptor agonists liraglutide and semaglutide for the treatment of weight regain after bariatric surgery: a retrospective …

AB Jensen, F Renström, S Aczél, P Folie… - Obesity surgery, 2023 - Springer
Purpose Weight regain after bariatric surgery occurs in up to a third of patients and reduces
treatment-associated health benefits. The efficacy of glucagon-like peptide-1 receptor …

The relationship between diabetes mellitus and gastric cancer and the potential benefits of metformin: an extensive review of the literature

CH Tseng - Biomolecules, 2021 - mdpi.com
The objective of this review is to summarize the findings of published research that
investigated the relationship between diabetes mellitus and gastric cancer (GCa) and the …

[HTML][HTML] Hypothalamic integrity is necessary for sustained weight loss after bariatric surgery: A prospective, cross-sectional study

U Dischinger, L Kötzner, P Kovatcheva-Datchary… - Metabolism, 2023 - Elsevier
Objective The hypothalamus is the main integrator of peripheral and central signals in the
control of energy homeostasis. Its functional relevance for the effectivity of bariatric surgery is …

Towards precision medicine in bariatric surgery prescription

SS Pereira, M Guimarães, MP Monteiro - Reviews in Endocrine and …, 2023 - Springer
Obesity is a complex, multifactorial and chronic disease. Bariatric surgery is a safe and
effective treatment intervention for obesity and obesity-related diseases. However, weight …

Obesity management in the primary prevention of hepatocellular carcinoma

ERM Zunica, EC Heintz, CL Axelrod, JP Kirwan - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an increasingly prevalent and deadly
disease driven in part by the rising obesity epidemic. Obesity causes HCC by initiating and …

Medical and surgical treatment of obesity

TJ Reid, J Korner - Medical Clinics, 2022 - medical.theclinics.com
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Diabetes mellitus and gastric cancer: correlation and potential mechanisms

L Wang, Z Zhang - Journal of Diabetes Research, 2023 - Wiley Online Library
This review summarizes the correlation between diabetes mellitus (DM) and gastric cancer
(GC) from the perspectives of epidemiology, drug use, and potential mechanisms. The …