Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Watching proteins wiggle: mapping structures with two-dimensional infrared spectroscopy

A Ghosh, JS Ostrander, MT Zanni - Chemical reviews, 2017 - ACS Publications
Proteins exhibit structural fluctuations over decades of time scales. From the picosecond
side chain motions to aggregates that form over the course of minutes, characterizing protein …

Selective methanol‐to‐formate electrocatalytic conversion on branched nickel carbide

J Li, R Wei, X Wang, Y Zuo, X Han, J Arbiol… - Angewandte …, 2020 - Wiley Online Library
A methanol economy will be favored by the availability of low‐cost catalysts able to
selectively oxidize methanol to formate. This selective oxidation would allow extraction of the …

Developing drug molecules for therapy with carbon monoxide

CC Romao, WA Blättler, JD Seixas… - Chemical Society …, 2012 - pubs.rsc.org
The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human
clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of …

[HTML][HTML] Carbon monoxide–physiology, detection and controlled release

SH Heinemann, T Hoshi, M Westerhausen… - Chemical …, 2014 - pubs.rsc.org
Carbon monoxide (CO) is increasingly recognized as a cell-signalling molecule akin to nitric
oxide (NO). CO has attracted particular attention as a potential therapeutic agent because of …

Carbon‐monoxide‐releasing molecules for the delivery of therapeutic CO in vivo

S García‐Gallego… - Angewandte Chemie …, 2014 - Wiley Online Library
The development of carbon‐monoxide‐releasing molecules (CORMs) as pharmaceutical
agents represents an attractive and safer alternative to administration of gaseous CO. Most …

Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology

N Bauer, Z Yuan, X Yang, B Wang - Biochemical Pharmacology, 2023 - Elsevier
Carbon monoxide (CO) is an endogenously produced gaseous signaling molecule with
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …

Red light‐triggered intracellular carbon monoxide release enables selective eradication of MRSA infection

J Cheng, G Gan, Z Shen, L Gao, G Zhang… - Angewandte …, 2021 - Wiley Online Library
Carbon monoxide (CO) is an important gaseous signaling molecule. The use of CO‐
releasing molecules such as metal carbonyls enables the elucidation of the pleiotropic …

Development of triggerable, trackable, and targetable carbon monoxide releasing molecules

LS Lazarus, AD Benninghoff… - Accounts of chemical …, 2020 - ACS Publications
Conspectus Carbon monoxide (CO) is a gaseous signaling molecule produced in humans
via the breakdown of heme in an O2-dependent reaction catalyzed by heme oxygenase …

Novel lead structures and activation mechanisms for CO‐releasing molecules (CORMs)

U Schatzschneider - British journal of pharmacology, 2015 - Wiley Online Library
Carbon monoxide (CO) is an endogenous small signalling molecule in the human body,
produced by the action of haem oxygenase on haem. Since it is very difficult to apply safely …