Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …

Abstract A primary calcium (Ca 2+) entry pathway into non-excitable cells is through the
store-operated Ca 2+ release activated Ca 2+(CRAC) channel. Ca 2+ entry into cells is …

Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic
reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but …

Orai channels mediate store-operated Ca 2+ signals crucial in regulating transcription in
many cell types, and implicated in numerous immunological and inflammatory disorders …

The store-operated calcium (Ca2+) channel Orai governs Ca2+ influx through the plasma
membrane of many non-excitable cells in metazoans. The channel opens in response to the …

Abstract Ca2+ release-activated Ca2+ (CRAC) channels, indispensable for the immune
system and various other human body functions, consist of two transmembrane (TM) …

The current optogenetic toolkit lacks a robust single-component Ca2+-selective ion channel
tailored for remote control of Ca2+ signaling in mammals. Existing tools are either derived …

Store‐operated Ca2+ entry through Orai1 channels is a primary mechanism for Ca2+ entry
in many cells and mediates numerous cellular effector functions ranging from gene …

The Orai channel is characterized by voltage independence, low conductance, and high
Ca2+ selectivity and plays an important role in Ca2+ influx through the plasma membrane …

The transmembrane docking of endoplasmic reticulum (ER) Ca2+-sensing STIM proteins
with plasma membrane (PM) Orai Ca2+ channels is a critical but poorly understood step in …