Factors in the pathophysiology of the liver ischemia-reperfusion injury

EE Montalvo-Jave, T Escalante-Tattersfield… - Journal of Surgical …, 2008 - Elsevier
Hepatic ischemia-reperfusion injury is commonplace in liver surgery, particularly in hepatic
transplantation, hepatic resection, and trauma. The signaling events contributing to local …

Ischemia‐reperfusion injury in chronic pressure ulcer formation: a skin model in the rat

SM Peirce, TC Skalak… - Wound repair and …, 2000 - Wiley Online Library
Most animal models of chronic pressure ulcers were designed to study only the role of
ischemic injury in wound formation, often using single applications of constant pressure. The …

The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat

A Nakai, S Kuroda, T Kristián, BK Siesjö - Neurobiology of disease, 1997 - Elsevier
Recirculation following 2 h of focal ischemia due to transient middle cerebral artery (MCA)
occlusion has previously been found to be accompanied by an initial, partial recovery of the …

Analysis of ischemia‐reperfusion injury in a microcirculatory model of pressure ulcers

S Tsuji, S Ichioka, N Sekiya… - Wound repair and …, 2005 - Wiley Online Library
The aim of this study was to establish a pressure ulcer model that visualizes the
microcirculation, and to examine the participation of ischemia‐reperfusion injury in the …

Beneficial effect of botulinum toxin A on Raynaud's phenomenon in Japanese patients with systemic sclerosis: a prospective, case series study

S Motegi, K Yamada, S Toki… - The Journal of …, 2016 - Wiley Online Library
Currently, there is no satisfactory treatment for Raynaud's phenomenon (RP) in systemic
sclerosis (SS c). Recently, it has been reported that botulinum toxin A (BTX‐A) injection was …

[HTML][HTML] Protective effect of MFG-E8 after cutaneous ischemia–reperfusion injury

A Uchiyama, K Yamada, B Perera, S Ogino… - Journal of investigative …, 2015 - Elsevier
We recently demonstrated that the secreted glycoprotein and integrin-ligand MFG-E8
promotes cutaneous wound healing by enhancing angiogenesis. Several studies have …

Protective effect of botulinum toxin A after cutaneous ischemia-reperfusion injury

A Uchiyama, K Yamada, B Perera, S Ogino… - Scientific reports, 2015 - nature.com
Abstract Botulinum toxin A (BTX-A) blocks the release of acetylcholine vesicles into the
synaptic space and has been clinically used for aesthetic indications, neuromuscular …

[HTML][HTML] The loss of MCP-1 attenuates cutaneous ischemia–reperfusion injury in a mouse model of pressure ulcer

Y Saito, M Hasegawa, M Fujimoto, T Matsushita… - Journal of Investigative …, 2008 - Elsevier
The formation of pressure ulcers is dependent on multiple factors including ischemia–
reperfusion (IR). This study assessed the mechanism of a previously reported murine model …

Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model

S Yamazaki, A Sekiguchi, A Uchiyama, C Fujiwara… - Scientific Reports, 2020 - nature.com
Several studies have demonstrated potential roles for apelin/APJ signaling in the regulation
of oxidative stress associated with ischemia-reperfusion (I/R) injury in several organs …

Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin

H Nakamura, A Sekiguchi, Y Ogawa… - Journal of …, 2019 - Elsevier
Background Zinc deficiency is believed to be a predisposing factor for the development and
intractable healing of pressure ulcers (PUs); however, the mechanisms of this association …