About a 100 years ago, the Drosophila white mutant marked the birth of Drosophila genetics.
The white gene turned out to encode the first well studied ABC transporter in arthropods …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …

The non-communicable disease, cancer, is one of the major causes of death across the
world and is forecast to increase by 75% to reach close to 25 million cases over the next two …

Monoclonal antibody MRK16 was used to determine the location of P-glycoprotein, the
product of the multidrug-resistance gene (MDR1), in normal human tissues. The protein was …

Endothelial cells of human capillary blood vessels at the blood-brain and other blood-tissue
barrier sites express P-glycoprotein as detected by mouse monoclonal antibodies against …

-jie Chen: Janice E. Chin: Kazumitsu Ueda, t las P. Clark, t $ Ira Pastan, t el M. Gottesman,?
and lgor B. Roninson” er for Genetics Iversity of Illinois College of Medicine at Chicago …

We have characterized the normal human tissue distribution and tumor expression of the
human multidrug resistance gene (MDR1) product P-glycoprotein (Pgp) by …

PK1 comprises doxorubicin covalently bound to N-(2-hydroxypropyl) methacrylamide
copolymer by a peptidyl linker. Following cellular uptake via pinocytosis, the linker is …

The non-ionic surfactants Cremophor® EL (CrEL; polyoxyethyleneglycerol triricinoleate 35)
and polysorbate 80 (Tween® 80; polyoxy-ethylene-sorbitan-20-monooleate) are widely …

The molecular components of the quality control system that rapidly degrades abnormal
membrane and secretory proteins have not been identified. The cystic fibrosis …