Planar polarity describes the coordinated polarisation of cells or structures in the plane of a
tissue. The patterning mechanisms that underlie planar polarity are well characterised in …

Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in
animal morphogenesis. Various cadherin-related molecules have also been identified …

The WAVE regulatory complex (WRC) controls actin cytoskeletal dynamics throughout the
cell by stimulating the actin-nucleating activity of the Arp2/3 complex at distinct membrane …

Polarized cell behaviors drive axis elongation in animal embryos, but the mechanisms
underlying elongation of many tissues remain unknown. Eggs of Drosophila undergo …

Tissue flow during morphogenesis is commonly driven by local constriction of cell cortices,
which is caused by the activation of actomyosin contractility. This can lead to long-range …

How organ-shaping mechanical imbalances are generated is a central question of
morphogenesis, with existing paradigms focusing on asymmetric force generation within …

Tissues use numerous mechanisms to change shape during development. The Drosophila
egg chamber is an organ-like structure that elongates to form an elliptical egg. During …

Understanding how molecular dynamics leads to cellular behaviours that ultimately sculpt
organs and tissues is a major challenge not only in basic developmental biology but also in …

Cells can migrate individually or collectively. Collective movement is common during normal
development and is also a characteristic of some cancers. This review discusses recent …

Sculpting organism shape requires that cells produce forces with proper directionality. Thus,
it is critical to understand how cells orient the cytoskeleton to produce forces that deform …