Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …

Over 75% of malaria-attributable deaths occur in children under the age of 5 years.
However, the first malaria vaccine recommended by the World Health Organization (WHO) …

A vaccine targeting multiple stages of the Plasmodium falciparum parasite life cycle is
desirable. The sporozoite surface Circumsporozoite Protein (CSP) is the target of leading …

After more than four decades of basic research and clinical trials, the World Health
Organization (WHO) has recommended the malaria vaccine RTS, S for widespread use …

Monoclonal antibodies are highly specific proteins that are cloned from a single B cell and
bind to a single epitope on a pathogen. These laboratory-made molecules can serve as …

Despite various public health strategies, malaria caused by Plasmodium falciparum
parasites remains a major global health challenge that requires development of new …

Plasmodium knowlesi is the leading cause of malaria in Malaysia. Serine Repeat Antigens
(SERAs) have an essential role in the parasite life cycle. However, genetic characterization …

L9 is a potent human monoclonal antibody (mAb) that preferentially binds two adjacent
NVDP minor repeats and cross-reacts with NANP major repeats of the Plasmodium …

Antibodies can prevent malaria by neutralizing the infectious Plasmodium falciparum
sporozoites (SPZ) before they establish an infection in the liver. Circumsporozoite protein …