Ovarian cancer: an overview

SM Penny - Radiologic technology, 2020 - Am Soc Radiol Tech
Ovarian cancer currently is the fifth leading cause of cancer-related deaths among women in
the United States, and approximately 140 000 women die globally per year of ovarian …

Causes and consequences of polycystic ovary syndrome: insights from Mendelian randomization

T Zhu, MO Goodarzi - The Journal of Clinical Endocrinology & …, 2022 - academic.oup.com
Context Although polycystic ovary syndrome (PCOS) is the most common endocrinopathy
affecting women of reproductive age, risk factors that may cause the syndrome are poorly …

Serum 25-hydroxyvitamin D and cancer risk: a systematic review of Mendelian randomization studies

T Lawler, S Warren Andersen - Nutrients, 2023 - mdpi.com
Epidemiological studies suggest that higher serum 25-hydroxyvitamin D is associated with
lower risk for several cancers, including breast, prostate, colorectal, and lung cancers. To …

Is type 2 diabetes causally associated with cancer risk? Evidence from a two-sample Mendelian randomization study

S Yuan, S Kar, P Carter, M Vithayathil, AM Mason… - Diabetes, 2020 - Am Diabetes Assoc
We conducted a two-sample Mendelian randomization study to investigate the causal
associations of type 2 diabetes mellitus (T2DM) with risk of overall cancer and 22 site …

Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities

IM McGrath, GW Montgomery… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Endometriosis remains a poorly understood disease, despite its high
prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of …

Systematic review of Mendelian randomization studies on risk of cancer

G Markozannes, A Kanellopoulou, O Dimopoulou… - BMC medicine, 2022 - Springer
Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

[HTML][HTML] A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes

S Mortlock, RI Corona, PF Kho, P Pharoah, JH Seo… - Cell Reports …, 2022 - cell.com
Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using
data from large endometriosis and EOC genome-wide association meta-analyses, we …

Vitamin D and human health: evidence from Mendelian randomization studies

A Fang, Y Zhao, P Yang, X Zhang… - European Journal of …, 2024 - Springer
We summarized the current evidence on vitamin D and major health outcomes from
Mendelian randomization (MR) studies. PubMed and Embase were searched for original …

Hormone therapy for ovarian cancer: Emphasis on mechanisms and applications

H Li, Y Liu, Y Wang, X Zhao, X Qi - Oncology reports, 2021 - spandidos-publications.com
Ovarian cancer (OC) remains the leading cause of mortality due to gynecological
malignancies. Epidemiological studies have demonstrated that steroid hormones released …

A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization

JS Ong, SC Dixon-Suen, X Han, J An… - Nature …, 2021 - nature.com
Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25 (OH) D) and
cancer have typically adopted a handful of variants and found no relationship between 25 …