RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

Ferroptosis, a form of regulated cell death, is initiated by oxidative perturbations of the
intracellular microenvironment, which is under the constitutive control of glutathione …

Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Iron is an essential trace element in the human body, but excess iron is toxic as it contributes
to oxidative damage. To keep iron concentration within the optimal physiologic range, iron …

Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

Iron is an essential dietary element. However, the ability of iron to cycle between oxidized
and reduced forms also renders it capable of contributing to free radical formation, which …

Demanded as an essential trace element that supports cell growth and basic functions, iron
can be harmful and cancerogenic though. By exchanging between its different oxidized …

The cardiovascular system requires iron to maintain its high energy demands and metabolic
activity. Iron plays a critical role in oxygen transport and storage, mitochondrial function, and …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Porphyrias, is a general term for a group of metabolic diseases that are genetic in nature. In
each specific porphyria the activity of specific enzymes in the heme biosynthetic pathway is …