Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery
J Li, R Zhao, P Miao, F Xu, J Chen, X Jiang… - European Journal of …, 2023 - Elsevier
Natural products have been utilized for medicinal purposes for millennia, endowing them
with a rich source of chemical scaffolds and pharmacological leads for drug discovery …
with a rich source of chemical scaffolds and pharmacological leads for drug discovery …
Natural antioxidants that act against Alzheimer's disease through modulation of the NRF2 pathway: a focus on their molecular mechanisms of action
Characterized by a complex pathophysiology that includes the intraneuronal formation of
neurofibrillary tangles and the extracellular deposition of β-amyloid plaques, Alzheimer's …
neurofibrillary tangles and the extracellular deposition of β-amyloid plaques, Alzheimer's …
Prophylactic effects of apigenin against hyperglycemia-associated amnesia via activation of the Nrf2/ARE pathway in zebrafish
The escalating focus on ageing-associated disease has generated substantial interest in the
phenomenon of cognitive impairment linked to diabetes. Hyperglycemia exacerbates …
phenomenon of cognitive impairment linked to diabetes. Hyperglycemia exacerbates …
Andrographolide attenuates short-term spatial and recognition memory impairment and neuroinflammation induced by a streptozotocin rat model of Alzheimer's …
LC Souza, MK Andrade, EM Azevedo, DC Ramos… - Neurotoxicity …, 2022 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder clinically manifested by a gradual
cognitive decline. Intracerebroventricular injection (ICV) of streptozotocin (STZ), a model of …
cognitive decline. Intracerebroventricular injection (ICV) of streptozotocin (STZ), a model of …
Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease
B Fonseca-Santos, CA Cazarin, PB da Silva… - … , Biology and Medicine, 2023 - Elsevier
Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects
around 6.5 million in the United States. Resveratrol is a chemical obtained from natural …
around 6.5 million in the United States. Resveratrol is a chemical obtained from natural …
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer's agents through pharmacophore-based virtual screening, molecular docking and …
Alzheimer's disease (AD) is the most prevalent form of neurodegenerative condition
distinguished by the deposition of amyloid beta plaques and neurofibrillary tangles in the …
distinguished by the deposition of amyloid beta plaques and neurofibrillary tangles in the …
Therapeutic approaches using natural substances on the streptozotocin-induced animal model of sporadic Alzheimer's disease: A systematic review
V Alexandre-Silva, GC Pereira, AM Ribeiro - Advances in Traditional …, 2024 - Springer
With the worldwide increase in life expectancy, cases of Alzheimer's disease (AD) have also
risen. Although new disease-modifying treatments are now available, novel drugs for the …
risen. Although new disease-modifying treatments are now available, novel drugs for the …
[HTML][HTML] α-Glucosidase, butyrylcholinesterase and acetylcholinesterase inhibitory activities of phenolic compounds from Carthamus tinctorius L. flowers: In silico and in …
Chemical investigation of Carthamus tinctorius L. flowers resulted in isolation of seven
metabolites that were identified as; p-Hydroxybenzoic acid (1), trans hydroxy cinnamic acid …
metabolites that were identified as; p-Hydroxybenzoic acid (1), trans hydroxy cinnamic acid …
The protective effect of Biotin supplementation and Swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer's disease: A …
S Almasi, MRJ Shirazi, MR Rezvani, M Ramezani… - Heliyon, 2024 - cell.com
Vitamin B (Vit B) plays a regulatory role in cognitive memory and learning. We examined the
biochemical and behavioral effects of biotin supplementation (BS) and swimming training …
biochemical and behavioral effects of biotin supplementation (BS) and swimming training …
Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia
This study examines the effectiveness of lupeol and metformin in a mouse model of
dementia generated by intracerebroventricular streptozotocin (icv, STZ). Dementia was …
dementia generated by intracerebroventricular streptozotocin (icv, STZ). Dementia was …