Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …

Magnetic resonance-guided focused ultrasound in combination with intravenously injected
microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta …

The blood-brain barrier (BBB) is an important factor limiting the effectiveness of central
nervous system (CNS) therapeutics. MR-guided focused ultrasound (MRgFUS) is a …

Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …

The blood-brain barrier (BBB) has long limited therapeutic access to brain tumor and
peritumoral tissue. In animals, MR-guided focused ultrasound (MRgFUS) with intravenously …

Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …

Focused ultrasound (FUS) in the presence of microbubbles can transiently open the blood-
brain barrier (BBB) to increase therapeutic agent penetration at the targeted brain site to …

Purpose: The blood–brain barrier (BBB) limits the efficacy of drug therapies for glioblastoma
(GBM). Preclinical data indicate that low-intensity pulsed ultrasound (LIPU) can transiently …