Inflammatory bowel disease and Parkinson's disease: common pathophysiological links
HS Lee, E Lobbestael, S Vermeire, J Sabino, I Cleynen - Gut, 2021 - gut.bmj.com
Inflammatory bowel disease and Parkinson's disease are chronic progressive disorders that
mainly affect different organs: the gut and brain, respectively. Accumulating evidence has …
mainly affect different organs: the gut and brain, respectively. Accumulating evidence has …
Animal models of α-synucleinopathy for Parkinson disease drug development
JB Koprich, LV Kalia, JM Brotchie - Nature Reviews Neuroscience, 2017 - nature.com
A major challenge in Parkinson disease (PD) will be to turn an emerging and expanding
pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets …
pipeline of novel disease-modifying candidate compounds into therapeutics. Novel targets …
Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson's disease patients
Background Parkinson's disease (PD) presently is conceptualized as a protein aggregation
disease in which pathology involves both the enteric and the central nervous system …
disease in which pathology involves both the enteric and the central nervous system …
Parkinson's disease biomarkers based on α‐synuclein
Parkinson's disease is the second most common neurodegenerative disorder after
Alzheimer's disease and is estimated to affect approximately 1–4% of individuals aged over …
Alzheimer's disease and is estimated to affect approximately 1–4% of individuals aged over …
Does Parkinson's disease start in the gut?
A Lionnet, L Leclair-Visonneau, M Neunlist… - Acta …, 2018 - Springer
Parkinson's disease (PD) is pathologically characterized by the presence of intraneuronal
inclusions, termed Lewy bodies and Lewy neurites, whose main component is alpha …
inclusions, termed Lewy bodies and Lewy neurites, whose main component is alpha …
Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease
M Vila - Movement Disorders, 2019 - Wiley Online Library
Neuromelanin, a dark brown intracellular pigment, has long been associated with
Parkinson's disease (PD). In PD, neuromelanin‐containing neurons preferentially …
Parkinson's disease (PD). In PD, neuromelanin‐containing neurons preferentially …
Value of in vivo α‐synuclein deposits in Parkinson's disease: A systematic review and meta‐analysis
K Tsukita, H Sakamaki‐Tsukita, K Tanaka… - Movement …, 2019 - Wiley Online Library
Previous studies that have investigated the potential of in vivo abnormal α‐synuclein
deposits as a pathological biomarker for PD included few participants and reported different …
deposits as a pathological biomarker for PD included few participants and reported different …
[HTML][HTML] Altered gut microbiome and intestinal pathology in Parkinson's disease
HL Chiang, CH Lin - Journal of movement disorders, 2019 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a common neurodegenerative disorder arising from an interplay
between genetic and environmental risk factors. Studies have suggested that the …
between genetic and environmental risk factors. Studies have suggested that the …
Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification
A Fenyi, L Leclair-Visonneau, T Clairembault… - Neurobiology of …, 2019 - Elsevier
Lewy bodies and neurites, the pathological signatures found in the central nervous system
of Parkinson's disease (PD) patients, are primarily composed of aggregated alpha-synuclein …
of Parkinson's disease (PD) patients, are primarily composed of aggregated alpha-synuclein …
Where and how alpha‐synuclein pathology spreads in Parkinson's disease
K Wakabayashi - Neuropathology, 2020 - Wiley Online Library
In Parkinson's disease (PD), neuronal alpha‐synuclein aggregates are distributed
throughout the nervous system, including the brain, spinal cord, sympathetic ganglia …
throughout the nervous system, including the brain, spinal cord, sympathetic ganglia …