Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII
JB Rodríguez-Molina, S West, LA Passmore - Molecular cell, 2023 - cell.com
Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …
and steady expression of some proteins as well as the rapidly changing production of other …
Splicing and transcription touch base: co-transcriptional spliceosome assembly and function
Several macromolecular machines collaborate to produce eukaryotic messenger RNA. RNA
polymerase II (Pol II) translocates along genes that are up to millions of base pairs in length …
polymerase II (Pol II) translocates along genes that are up to millions of base pairs in length …
Control of RNA Pol II speed by PNUTS-PP1 and Spt5 dephosphorylation facilitates termination by a “sitting duck torpedo” mechanism
MA Cortazar, RM Sheridan, B Erickson, N Fong… - Molecular cell, 2019 - cell.com
Control of transcription speed, which influences many co-transcriptional processes, is poorly
understood. We report that PNUTS-PP1 phosphatase is a negative regulator of RNA …
understood. We report that PNUTS-PP1 phosphatase is a negative regulator of RNA …
Small nucleolar RNAs tell a different tale
J Kufel, P Grzechnik - Trends in Genetics, 2019 - cell.com
Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …
Integrator is a genome-wide attenuator of non-productive transcription
S Lykke-Andersen, K Žumer, EŠ Molska, JO Rouvière… - Molecular cell, 2021 - cell.com
Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the
cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act …
cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act …
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
Transcription progression is governed by multitasking regulators including SPT5, an
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …
A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes
JD Eaton, L Francis, L Davidson… - Genes & …, 2020 - genesdev.cshlp.org
The allosteric and torpedo models have been used for 30 yr to explain how transcription
terminates on protein-coding genes. The former invokes termination via conformational …
terminates on protein-coding genes. The former invokes termination via conformational …
The pausing zone and control of RNA polymerase II elongation by Spt5: Implications for the pause-release model
The pause-release model of transcription proposes that 40–100 bases from the start site
RNA Pol II pauses, followed by release into productive elongation. Pause release is …
RNA Pol II pauses, followed by release into productive elongation. Pause release is …
Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp
During transcription, RNA polymerase II (Pol II) associates with the conserved elongation
factor DSIF. DSIF renders the elongation complex stable and functions during Pol II pausing …
factor DSIF. DSIF renders the elongation complex stable and functions during Pol II pausing …
Termination of transcription by RNA polymerase II: BOOM!
JD Eaton, S West - Trends in Genetics, 2020 - cell.com
RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units–a
reaction always brought to a close by its termination. Because Pol II transcribes multiple …
reaction always brought to a close by its termination. Because Pol II transcribes multiple …