Environmental determinants of cardiovascular disease: lessons learned from air pollution

SG Al-Kindi, RD Brook, S Biswal… - Nature Reviews …, 2020 - nature.com
Air pollution is well recognized as a major risk factor for chronic non-communicable
diseases and has been estimated to contribute more to global morbidity and mortality than …

Air Pollution and Cardiovascular Disease: JACC State-of-the-Art Review

S Rajagopalan, SG Al-Kindi, RD Brook - Journal of the American College of …, 2018 - jacc.org
Abstract Fine particulate matter< 2.5 μm (PM2. 5) air pollution is the most important
environmental risk factor contributing to global cardiovascular (CV) mortality and disability …

Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice

S Shan, Y Zhang, H Zhao, T Zeng, X Zhao - Chemosphere, 2022 - Elsevier
Microplastics (MPs) have been well demonstrated as potential threats to the ecosystem,
whereas the neurotoxicity of MPs in mammals remains to be elucidated. The current study …

Air pollution and dementia: a systematic review

R Peters, N Ee, J Peters, A Booth… - Journal of …, 2019 - content.iospress.com
Background: Both air pollution and dementia are current and growing global issues. There
are plausible links between exposure to specific air pollutants and dementia. Objective: To …

Toxicology of nanoparticles in drug delivery

S Sharma, R Parveen, BP Chatterji - Current pathobiology reports, 2021 - Springer
Nanoparticles have revolutionized biomedicine especially in the field of drug delivery due to
their intriguing properties such as systemic stability, level of solubility, and target site …

Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier

J Li, M Zheng, O Shimoni, WA Banks, AI Bush… - Advanced …, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1/M2 microglial polarization in an Alzheimer's disease model

C Ren, D Li, Q Zhou, X Hu - Biomaterials, 2020 - Elsevier
Alzheimer's disease (AD) is one of the most common age-associated brain diseases and is
induced by the accumulation of amyloid beta (Aβ) and oxidative stress. Many studies have …

How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects

J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
Biological barriers are essential physiological protective systems and obstacles to drug
delivery. Nanoparticles (NPs) can access the paracellular route of biological barriers, either …

Aggf1 attenuates neuroinflammation and BBB disruption via PI3K/Akt/NF-κB pathway after subarachnoid hemorrhage in rats

Q Zhu, B Enkhjargal, L Huang, T Zhang, C Sun… - Journal of …, 2018 - Springer
Background Neuroinflammation and blood-brain barrier (BBB) disruption are two critical
mechanisms of subarachnoid hemorrhage (SAH)-induced brain injury, which are closely …

Early life stress, air pollution, inflammation, and disease: an integrative review and immunologic model of social-environmental adversity and lifespan health

HAO Alvarez, LD Kubzansky, MJ Campen… - Neuroscience & …, 2018 - Elsevier
Socially disadvantaged individuals are at greater risk for simultaneously being exposed to
adverse social and environmental conditions. Although the mechanisms underlying joint …