Many neurodegenerative diseases are neuropathologically characterized by neuronal loss,
gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau …

Hyperphosphorylated tau aggregates, also known as neurofibrillary tangles, are a hallmark
neuropathological feature of Alzheimer's disease (AD). Molecular imaging of tau by positron …

Amyloid-β deposition into plaques is a pathologic hallmark of Alzheimer disease appearing
years before the onset of symptoms. Although cerebral amyloid-β deposition occurs on a …

Pathological accumulated misfolded tau underlies various neurodegenerative diseases and
associated clinical syndromes. To diagnose those diseases reliable before death or even at …

Abstract Background A Phase II proof of concept (POC) randomized clinical trial was
conducted to evaluate the effects of rasagiline, a monoamine oxidase B (MAO‐B) inhibitor …

This article presents an overview of imaging agents for PET that have been applied for
research and diagnostic purposes in patients affected by dementia. Classified by the target …

Corticobasal syndrome (CBS) is characterized by symptoms related to the asymmetric
involvement of the cerebral cortex and basal ganglia. However, early detection of …

Monoamine oxidase B (MAO‐B) is an enzyme localized to the outer mitochondrial
membrane and highly concentrated in astrocytes. Temporal changes in regional MAO‐B …

Background 18 F-THK5351 PET estimates the concentrations of monoamine oxidase B
(MAO-B) that are preferentially located in astrocytes and can be used to visualize and …

Abstract Purpose [18F]-labeled positron emission tomography (PET) radioligands permit in
vivo assessment of Alzheimer's disease biomarkers, including aggregated neurofibrillary tau …