In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …

Protein kinase RNA‐like ER kinase (PERK) is an endoplasmic reticulum (ER) stress sensor
that responds to the accumulation of misfolded proteins. Once activated, PERK initiates …

Recent studies undoubtedly show the importance of inter organellar connections to maintain
cellular homeostasis. In normal physiological conditions or in the presence of cellular and …

Cellular senescence constitutes a generally irreversible proliferation barrier, accompanied
by macromolecular damage and metabolic rewiring. Several senescence types have been …

Redox-active, strongly magnetic, combustion and friction-derived nanoparticles (CFDNPs)
are abundant in particulate matter air pollution. Urban children and young adults with …

Energetically speaking, ribosome biogenesis is by far the most costly process of the cell and,
therefore, must be highly regulated in order to avoid unnecessary energy expenditure. Not …

Stress granules (SGs) are membraneless organelles composed of mRNAs and RNA binding
proteins which undergo assembly in response to stress-induced inactivation of translation …

Protein expression evolves under greater evolutionary constraint than mRNA levels, and
translation efficiency represents a primary determinant of protein levels during stimuli …

Queuosine (Q) is a conserved hypermodification of the wobble base of tRNA containing
GUN anticodons but the physiological consequences of Q deficiency are poorly understood …

The development of novel therapeutics that exploit alterations in the activation state of key
cellular signaling pathways due to mutations in upstream regulators has generated the field …