Fragment-based drug discovery (FBDD) is a powerful method to develop potent small-
molecule compounds starting from fragments binding weakly to targets. As FBDD exhibits …

Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the
pharmaceutical sciences. We summarize successful fragment-to-lead studies that were …

The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

Enoyl acyl carrier protein reductase (InhA) is a key enzyme involved in fatty acid synthesis
mainly mycolic acid biosynthesis that is a part of NADH dependent acyl carrier protein …

Abstract Substituted aldehydes, ethyl 2-(2-amino-thiazol-4-yl) acetate), and 2-
mercaptoacetic acid, in a three-component one-pot green synthetic approach afforded 2 …

Mycobacterium tuberculosis is the causative pathogen of the pulmonary disease
tuberculosis. Despite the availability of effective treatment programs, there is a global pursuit …

Solution nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to study
structures and dynamics of biomolecules under physiological conditions. As there are …

The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion
of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a worldwide
scourge with more than 10 million people affected yearly. Among the proteins essential for …

The long-term treatment of tuberculosis (TB) sometimes leads to nonadherence to treatment,
resulting in multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis …