The tumor microenvironment (TME) is composed of various cell types embedded in an
altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also …

Diabetic nephropathy (DN) is the leading cause of chronic kidney disease in the United
States and is a major cause of cardiovascular disease and death. DN develops insidiously …

The remodeling of the extracellular matrix (ECM) by several protease families releases a
number of bioactive fragments, which regulate numerous biological processes such as …

Glioblastoma multiforms (GBMs) are highly vascularized brain tumors containing a
subpopulation of multipotent cancer stem cells. These cells closely interact with endothelial …

Successful clinical methods for tumor elimination include a combination of surgical
resection, radiotherapy, and chemotherapy. Radiotherapy is one of the crucial components …

BACKGROUND & AIMS: Hepatopulmonary syndrome (HPS) affects 10%–30% of patients
with cirrhosis and portal hypertension and significantly increases mortality. Studies in …

Endostatin is an endogenous inhibitor of angiogenesis. Although several endothelial cell
surface molecules have been reported to interact with endostatin, its molecular mechanism …

Proliferating cancer cells secrete a multitude of factors impacting metabolism, interorgan
communication, and tumor progression. The distribution of tumor-derived factors to distant …

Endostatin is a C-terminal proteolytic fragment of collagen XVIII that is localized in vascular
basement membrane zones in various organs. It binds to heparin/heparan sulfate and to a …

BACKGROUND The prostate produces high levels of prostate‐specific antigen (PSA), which
has been shown to exert anti‐angiogenic properties and thus might slow down prostate …