Clinical updates in adult immune thrombocytopenia
MP Lambert, TB Gernsheimer - Blood, The Journal of the …, 2017 - ashpublications.org
Immune thrombocytopenia (ITP) occurs in 2 to 4/100 000 adults and results in variable
bleeding symptoms and thrombocytopenia. In the last decade, changes in our …
bleeding symptoms and thrombocytopenia. In the last decade, changes in our …
Emerging concepts in immune thrombocytopenia
M Swinkels, M Rijkers, J Voorberg… - Frontiers in …, 2018 - frontiersin.org
Immune thrombocytopenia (ITP) is an autoimmune disease defined by low platelet counts
which presents with an increased bleeding risk. Several genetic risk factors (eg …
which presents with an increased bleeding risk. Several genetic risk factors (eg …
Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by
autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests …
autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests …
Mechanisms of platelet clearance and translation to improve platelet storage
Hundreds of billions of platelets are cleared daily from circulation via efficient and highly
regulated mechanisms. These mechanisms may be stimulated by exogenous reagents or …
regulated mechanisms. These mechanisms may be stimulated by exogenous reagents or …
The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling
R Grozovsky, AJ Begonja, K Liu, G Visner… - Nature medicine, 2015 - nature.com
Abstract The hepatic Ashwell-Morell receptor (AMR) can bind and remove desialylated
platelets. Here we demonstrate that platelets become desialylated as they circulate and age …
platelets. Here we demonstrate that platelets become desialylated as they circulate and age …
[HTML][HTML] Platelets in hemostasis and thrombosis: Novel mechanisms of fibrinogen-independent platelet aggregation and fibronectin-mediated protein wave of …
Platelets are small anucleate cells generated from megakaryocytes in the bone marrow.
Although platelet generation, maturation, and clearance are still not fully understood …
Although platelet generation, maturation, and clearance are still not fully understood …
Regulating billions of blood platelets: glycans and beyond
R Grozovsky, S Giannini, H Falet… - Blood, The Journal of …, 2015 - ashpublications.org
The human body produces and removes 1011 platelets daily to maintain a normal steady
state platelet count. Platelet production must be regulated to avoid spontaneous bleeding or …
state platelet count. Platelet production must be regulated to avoid spontaneous bleeding or …
[HTML][HTML] Metalloproteinases in extracellular vesicles
M Shimoda, R Khokha - Biochimica et Biophysica Acta (BBA)-Molecular …, 2017 - Elsevier
Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular
communications in local and distant microenvironments under patho/physiological …
communications in local and distant microenvironments under patho/physiological …
Sialidase inhibitors with different mechanisms
JM Keil, GR Rafn, IM Turan, MA Aljohani… - Journal of medicinal …, 2022 - ACS Publications
Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …
Storage of platelets at 4 C in platelet additive solutions prevents aggregate formation and preserves platelet functional responses
BACKGROUND Platelet (PLT) storage has been limited to 5 days at room temperature due
to metabolic decline and risk for bacterial contamination. Refrigeration preserves PLT …
to metabolic decline and risk for bacterial contamination. Refrigeration preserves PLT …