Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens

E Ksiezopolska, T Gabaldón - Genes, 2018 - mdpi.com
Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …

The quiet and underappreciated rise of drug-resistant invasive fungal pathogens

A Arastehfar, C Lass-Flörl, R Garcia-Rubio… - Journal of Fungi, 2020 - mdpi.com
Human fungal pathogens are attributable to a significant economic burden and mortality
worldwide. Antifungal treatments, although limited in number, play a pivotal role in …

Candida glabrata: a review of its features and resistance

CF Rodrigues, S Silva, M Henriques - European journal of clinical …, 2014 - Springer
Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and
vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous …

Candida glabrata: A Lot More Than Meets the Eye

K Kumar, F Askari, MS Sahu, R Kaur - Microorganisms, 2019 - mdpi.com
Candida glabrata is an opportunistic human fungal pathogen that causes superficial
mucosal and life-threatening bloodstream infections in individuals with a compromised …

Candida glabrata Biofilms: How Far Have We Come?

CF Rodrigues, ME Rodrigues, S Silva, M Henriques - Journal of fungi, 2017 - mdpi.com
Infections caused by Candida species have been increasing in the last decades and can
result in local or systemic infections, with high morbidity and mortality. After Candida …

Aneuploidy in yeast: Segregation error or adaptation mechanism?

C Gilchrist, R Stelkens - Yeast, 2019 - Wiley Online Library
Aneuploidy is the loss or gain of chromosomes within a genome. It is often detrimental and
has been associated with cell death and genetic disorders. However, aneuploidy can also …

Evolutionary genomics of yeast pathogens in the Saccharomycotina

T Gabaldón, MA Naranjo-Ortíz… - FEMS yeast …, 2016 - academic.oup.com
Saccharomycotina comprises a diverse group of yeasts that includes numerous species of
industrial or clinical relevance. Opportunistic pathogens within this clade are often assigned …

Adhesins in Candida glabrata

B Timmermans, A De Las Peñas, I Castaño… - Journal of Fungi, 2018 - mdpi.com
The human fungal pathogen Candida glabrata is causing more and more problems in
hospitals, as this species shows an intrinsic antifungal drug resistance or rapidly becomes …

Patterns of genomic variation in the opportunistic pathogen Candida glabrata suggest the existence of mating and a secondary association with humans

L Carreté, E Ksiezopolska, C Pegueroles… - Current Biology, 2018 - cell.com
Candida glabrata is an opportunistic fungal pathogen that ranks as the second most
common cause of systemic candidiasis. Despite its genus name, this yeast is more closely …

Genetic Drivers of Multidrug Resistance in Candida glabrata

KR Healey, C Jimenez Ortigosa, E Shor… - Frontiers in …, 2016 - frontiersin.org
Both the incidence of invasive fungal infections and rates of multidrug resistance associated
with fungal pathogen Candida glabrata have increased in recent years. In this perspective …