A World Health Organization (WHO) classification of hematopoietic and lymphoid
neoplasms has recently been published. This classification was developed through the …

Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to
morphology, immunophenotyping, germline and somatic cytogenetic and genetic …

This review highlights new findings that have deepened our understanding of the
mechanisms of leukemogenesis, therapy and resistance in acute promyelocytic leukemia …

Acute promyelocytic leukemia (APL) is typified by the t (15; 17), generating the PML-RARα
fusion and predicting a beneficial response to retinoids. However, a sizeable minority of APL …

Pelger–Huët anomaly (PHA; OMIM* 169400) is an autosomal dominant disorder
characterized by abnormal nuclear shape and chromatin organization in blood …

Vitamin D 3 upregulated protein 1 (VDUP1) is a 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D
3) upregulated protein, and it is induced by various stresses. In human tumor tissues …

Multi-parameter flow cytometry, molecular genetics, and cytogenetic studies have all
contributed to new classification of leukemia. In this review we discuss immunophenotypic …

Acute promyelocytic leukemia (APL) is characterized by the accumulation of promyelocytes
in bone marrow. More than 95% of patients with this disease belong to typical APL, which …

Acute promyelocytic leukemia (APL) is characterized by a number of features that underpin
the need for rapid and accurate diagnosis and demand a highly specific treatment approach …

Acute promyelocytic leukemia (APL) has been recognized as a distinct clinical entity for over
40 years. Although relatively rare among hematopoietic malignancies (approximately 10 …