The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

The blood-brain barrier (BBB) is a major functional barrier in the central nervous system
(CNS), and inhibits the extravasation of intravascular contents and transports various …

Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous
system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in …

Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally
compose tripartite synapses, blood–brain barrier, and the neurovascular unit and perform …

Background and Purpose—Blood-brain barrier (BBB) disruption is a critical pathological
feature after stroke. MicroRNA-126 (miR-126) maintains BBB integrity by regulating …

Stroke is the number one cause of neurological dysfunction in adults and has a heavy
socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting …

Non-coding RNAs (ncRNAs) are a class of functional RNAs that regulate gene expression in
a post-transcriptional manner. NcRNAs include microRNAs, long non-coding RNAs and …

Ischemic stroke is a disease with high morbidity and mortality worldwide, which often places
an additional strain on families and society due to the poor prognosis. Blood brain-barrier …

Stroke continues to be the third-leading cause of death and disability worldwide. The limited
availability of diagnostic tools approved therapeutics and biomarkers that help monitor …