Bioinformatics methods for mass spectrometry-based proteomics data analysis
Recent advances in mass spectrometry (MS)-based proteomics have enabled tremendous
progress in the understanding of cellular mechanisms, disease progression, and the …
progress in the understanding of cellular mechanisms, disease progression, and the …
[HTML][HTML] Data-analysis strategies for image-based cell profiling
Image-based cell profiling is a high-throughput strategy for the quantification of phenotypic
differences among a variety of cell populations. It paves the way to studying biological …
differences among a variety of cell populations. It paves the way to studying biological …
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
AR Pombo Antunes, I Scheyltjens, F Lodi… - Nature …, 2021 - nature.com
Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …
Application of an artificial neural network to optimise energy inputs: An energy-and cost-saving strategy for commercial poultry farms
E Elahi, Z Zhang, Z Khalid, H Xu - Energy, 2022 - Elsevier
The current study estimates target values of energy inputs along with an assessment of
energy-and cost-saving strategies for poultry farms. In 2019, cross-sectional data were …
energy-and cost-saving strategies for poultry farms. In 2019, cross-sectional data were …
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort
The drivers of critical coronavirus disease 2019 (COVID-19) remain unknown. Given major
confounding factors such as age and comorbidities, true mediators of this condition have …
confounding factors such as age and comorbidities, true mediators of this condition have …
[PDF][PDF] A comprehensive subcellular atlas of the Toxoplasma proteome via hyperLOPIT provides spatial context for protein functions
Apicomplexan parasites cause major human disease and food insecurity. They owe their
considerable success to highly specialized cell compartments and structures. These …
considerable success to highly specialized cell compartments and structures. These …
Proteome-wide identification of ubiquitin interactions using UbIA-MS
Ubiquitin-binding proteins play an important role in eukaryotes by translating differently
linked polyubiquitin chains into proper cellular responses. Current knowledge about …
linked polyubiquitin chains into proper cellular responses. Current knowledge about …
The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron
The ubiquitin E3 ligase substrate adapter cereblon (CRBN) is a target of thalidomide and
lenalidomide, therapeutic agents used in the treatment of haematopoietic malignancies …
lenalidomide, therapeutic agents used in the treatment of haematopoietic malignancies …
[PDF][PDF] Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease
OM de Goede, DC Nachun, NM Ferraro… - Cell, 2021 - cell.com
Long non-coding RNA (lncRNA) genes have well-established and important impacts on
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still …
molecular and cellular functions. However, among the thousands of lncRNA genes, it is still …
Distribution of miRNA expression across human tissues
We present a human miRNA tissue atlas by determining the abundance of 1997 miRNAs in
61 tissue biopsies of different organs from two individuals collected post-mortem. One …
61 tissue biopsies of different organs from two individuals collected post-mortem. One …