Parasites are responsible for a wide variety of infectious diseases in human as well as in
domestic and wild animals, causing an enormous health and economical blight. Current …

The energy metabolism of Trypanosomatidae has been the subject of many reviews during
the past decade. In recent years, however, new data have led to a more complete picture of …

Systems analyses have facilitated the characterization of metabolic networks of several
organisms. We have reconstructed the metabolic network of Leishmania major, a poorly …

In total, 37080 protein sequences of the three trypanosomatids Leishmania major,
Trypanosoma brucei and Trypanosoma cruzi, were used to predict the trypanosomatid …

For many years, the purine salvage pathway of parasitic protozoa has been regarded as an
attractive chemotherapeutic target. Parasitic protozoa lack de novo synthesis and rely …

Purine nucleotides function in a variety of vital cellular and metabolic processes including
energy production, cell signaling, synthesis of vitamin-derived cofactors and nucleic acids …

Certain bacteria are resistant to antibiotics and can even transform antibiotics in the
environment. It is unclear how the molecular mechanisms underlying the resistance and …

Peroxisomes of higher eukaryotes, glycosomes of kinetoplastids, and glyoxysomes of plants
are related microbody organelles that perform differing metabolic functions tailored to their …

Purines and pyrimidines are indispensable to all life, performing many vital functions for
cells: ATP serves as the universal currency of cellular energy, cAMP and cGMP are key …

Purine phosphoribosyltransferases (PRTs) 1 of microbes and mammals are enzymes that
catalyze the recovery of preformed bases for use in cellular metabolism. In free living …