CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Muscle glycogen is the main substrate during high-intensity exercise and large reductions
can occur after relatively short durations. Moreover, muscle glycogen is stored …

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel
Foods and Food Allergens (NDA) derived dietary reference values (DRV s) for sodium …

Statins are effective drugs to reduce cardiovascular events secondary to dyslipidemia;
however, they cause frequent undesirable side effects. The incidence of statin-induced …

In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …

The nondystrophic myotonias are rare muscle hyperexcitability disorders caused by gain‐of‐
function mutations in the SCN4A gene or loss‐of‐function mutations in the CLCN1 gene …

The discovery of ClC proteins at the beginning of the 1990s was important for the
development of the Cl-transport research field. ClCs form a large family of proteins that …

The integrity and preservation of the neuromuscular junction (NMJ), the interface between
the motor neuron and skeletal muscle, is critical for maintaining a healthy skeletal muscle …

The excretory system of the nematode Caenorhabditis elegans is a superb model of tubular
organogenesis involving a minimum of cells. The system consists of just three unicellular …

Myotonic disorders are inherited neuromuscular diseases divided into dystrophic myotonias
and non-dystrophic myotonias (NDM). The latter is a group of dominant or recessive …