The potential of activator protein 1 (AP-1) in cancer targeted therapy
D Song, Y Lian, L Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Activator protein-1 (AP-1) is a transcription factor that consists of a diverse group of members
including Jun, Fos, Maf, and ATF. AP-1 involves a number of processes such as …
including Jun, Fos, Maf, and ATF. AP-1 involves a number of processes such as …
[HTML][HTML] A multi-omics approach to reveal critical mechanisms of activator protein 1 (AP-1)
F Li, J Tian, L Zhang, H He, D Song - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Abstract The Activator Protein 1 (AP-1) transcription factor complex plays a pivotal role in the
regulation of cancer-related genes, influencing cancer cell proliferation, invasion, migration …
regulation of cancer-related genes, influencing cancer cell proliferation, invasion, migration …
The human adenovirus E1B-55K oncoprotein coordinates cell transformation through regulation of DNA-bound host transcription factors
K von Stromberg, L Seddar, WH Ip… - Proceedings of the …, 2023 - National Acad Sciences
The multifunctional adenovirus E1B-55K oncoprotein can induce cell transformation in
conjunction with adenovirus E1A gene products. Previous data from transient expression …
conjunction with adenovirus E1A gene products. Previous data from transient expression …
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
EJ Ruiz, A Pinto-Fernandez, AP Turnbull, L Lan… - Elife, 2021 - elifesciences.org
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an
incidence of over 600,000 cases per year. Treatment options are limited, and patient's 5 …
incidence of over 600,000 cases per year. Treatment options are limited, and patient's 5 …
Integrated analysis of single-cell and bulk RNA-sequencing identifies a signature based on T-cell marker genes to predict prognosis and therapeutic response in lung …
X Shi, A Dong, X Jia, G Zheng, N Wang… - Frontiers in …, 2022 - frontiersin.org
Cancer immunotherapy is an increasingly successful strategy for treating patients with
advanced or conventionally drug-resistant cancers. T cells have been proved to play …
advanced or conventionally drug-resistant cancers. T cells have been proved to play …
p53 inhibitor iASPP is an unexpected suppressor of KRAS and inflammation-driven pancreatic cancer
P Miller, EH Akama-Garren, RP Owen… - Cell Death & …, 2023 - nature.com
Oncogenic KRAS activation, inflammation and p53 mutation are key drivers of pancreatic
cancer (PC) development. Here we report iASPP, an inhibitor of p53, as a paradoxical …
cancer (PC) development. Here we report iASPP, an inhibitor of p53, as a paradoxical …
Jun/Fos promotes migration and invasion of hepatocellular carcinoma cells by enhancing BORIS promoter activity
L Xian, Y Xiong, L Qin, L Wei, S Zhou, Q Wang… - … International Journal of …, 2024 - Elsevier
Abstract The Brother of the Regulator of Imprinted Sites (BORIS), as a specific indicator of
hepatocellular carcinoma, exhibits a significant increase in expression. However, its …
hepatocellular carcinoma, exhibits a significant increase in expression. However, its …
Construction of atrial fibrillation‐related circRNA/lncRNA‐miRNA‐mRNA regulatory network and analysis of potential biomarkers
J Wen, Z Ruan, F Wang, G Chen, J Zhu… - Journal of Clinical …, 2023 - Wiley Online Library
Background The specific pathogenesis of atrial fibrillation (AF) remains unclear. In this study,
we examined the expression of differential messenger RNAs (mRNAs), circular RNAs …
we examined the expression of differential messenger RNAs (mRNAs), circular RNAs …
Single-cell RNA-sequencing data analysis reveals a highly correlated triphasic transcriptional response to SARS-CoV-2 infection
PA Gutiérrez, SF Elena - Communications Biology, 2022 - nature.com
Single-cell RNA sequencing (scRNA-seq) is currently one of the most powerful techniques
available to study the transcriptional response of thousands of cells to an external …
available to study the transcriptional response of thousands of cells to an external …
Exploration of potential targets and mechanisms of fisetin in the treatment of non‐small‐cell lung carcinoma via network pharmacology and in vitro validation
J Ling, Y Wang, L Ma, A Chang… - Evidence‐Based …, 2022 - Wiley Online Library
Purpose. The morbidity and fatality rates of non‐small‐cell lung cancer (NSCLC) were high,
although a combination of multiple treatments was used. Fisetin, a small flavonoid …
although a combination of multiple treatments was used. Fisetin, a small flavonoid …