[HTML][HTML] The initial interplay between HIV and mucosal innate immunity
V Caputo, M Libera, S Sisti, B Giuliani… - Frontiers in …, 2023 - frontiersin.org
Human Immunodeficiency Virus (HIV) is still one of the major global health issues, and
despite significant efforts that have been put into studying the pathogenesis of HIV infection …
despite significant efforts that have been put into studying the pathogenesis of HIV infection …
[HTML][HTML] Genetic and epigenetic background of diabetic kidney disease
N Sandholm, EH Dahlström, PH Groop - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is a severe diabetic complication that affects up to half of the
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …
individuals with diabetes. Elevated blood glucose levels are a key underlying cause of DKD …
[HTML][HTML] DNA methylation markers for kidney function and progression of diabetic kidney disease
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …
[HTML][HTML] Meta-analyses identify DNA methylation associated with kidney function and damage
Chronic kidney disease is a major public health burden. Elevated urinary albumin-to-
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic …
[HTML][HTML] Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
WA van der Heijden, L Van de Wijer, F Keramati… - JCI insight, 2021 - ncbi.nlm.nih.gov
Chronic inflammation and immune dysfunction play a key role in the development of non-
AIDS–related comorbidities. The aim of our study was to characterize the functional …
AIDS–related comorbidities. The aim of our study was to characterize the functional …
Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease
Poor metabolic control and host genetic predisposition are critical for diabetic kidney
disease (DKD) development. The epigenome integrates information from sequence …
disease (DKD) development. The epigenome integrates information from sequence …
[HTML][HTML] Batch-effect detection, correction and characterisation in Illumina HumanMethylation450 and MethylationEPIC BeadChip array data
Background Genomic technologies can be subject to significant batch-effects which are
known to reduce experimental power and to potentially create false positive results. The …
known to reduce experimental power and to potentially create false positive results. The …
[HTML][HTML] Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Background DNA methylation (DNAm) is associated with gene regulation and estimated
glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more …
glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more …
[HTML][HTML] Getting out of crises: Environmental, social-ecological and evolutionary research is needed to avoid future risks of pandemics
D Destoumieux-Garzón, F Matthies-Wiesler… - Environment …, 2022 - Elsevier
Abstract The implementation of One Health/EcoHealth/Planetary Health approaches has
been identified as key (i) to address the strong interconnections between risk for pandemics …
been identified as key (i) to address the strong interconnections between risk for pandemics …
[HTML][HTML] Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression
Despite significant advances in the treatment and care of people with HIV (PWH), several
challenges remain in our understanding of disease pathogenesis to improve patient care …
challenges remain in our understanding of disease pathogenesis to improve patient care …