Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease
During the last century, there has been an increasing prevalence of hyperuricaemia noted in
many populations. While uric acid is usually discussed in the context of gout …
many populations. While uric acid is usually discussed in the context of gout …
Risk factors for type 2 diabetes mellitus: an exposure-wide umbrella review of meta-analyses
Background Type 2 diabetes mellitus (T2DM) is a global epidemic associated with
increased health expenditure, and low quality of life. Many non-genetic risk factors have …
increased health expenditure, and low quality of life. Many non-genetic risk factors have …
Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by the National Kidney …
Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …
[HTML][HTML] Physiological functions and pathogenic potential of uric acid: A review
Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the
end product of an exogenous pool of purines, and endogenously from damaged, dying and …
end product of an exogenous pool of purines, and endogenously from damaged, dying and …
Physiology of hyperuricemia and urate-lowering treatments
CL Benn, P Dua, R Gurrell, P Loudon, A Pike… - Frontiers in …, 2018 - frontiersin.org
Gout is the most common form of inflammatory arthritis and is a multifactorial disease
typically characterized by hyperuricemia and monosodium urate crystal deposition …
typically characterized by hyperuricemia and monosodium urate crystal deposition …
Impact of comorbidities on gout and hyperuricaemia: an update on prevalence and treatment options
T Bardin, P Richette - BMC medicine, 2017 - Springer
Gout, the most prevalent inflammatory arthritis worldwide, is associated with cardiovascular
and renal diseases, and is an independent predictor of premature death. The frequencies of …
and renal diseases, and is an independent predictor of premature death. The frequencies of …
Excess comorbidities in gout: the causal paradigm and pleiotropic approaches to care
HK Choi, N McCormick, C Yokose - Nature Reviews Rheumatology, 2022 - nature.com
Gout is a common hyperuricaemic metabolic condition that leads to painful inflammatory
arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions …
arthritis and a high comorbidity burden, especially cardiometabolic-renal (CMR) conditions …
An update on the genetics of hyperuricaemia and gout
A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …
the formation of monosodium urate crystals. The clinical features of gout result from an …
Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian …
Objective To map the diverse health outcomes associated with serum uric acid (SUA) levels.
Design Umbrella review. Data sources Medline, Embase, Cochrane Database of Systematic …
Design Umbrella review. Data sources Medline, Embase, Cochrane Database of Systematic …
Effects of uric acid on diabetes mellitus and its chronic complications
Q Xiong, J Liu, Y Xu - International journal of endocrinology, 2019 - Wiley Online Library
With the deepening of the researches on uric acid, especially in the study of metabolic
diseases, uric acid has been found to be closely related to obesity, metabolic syndrome …
diseases, uric acid has been found to be closely related to obesity, metabolic syndrome …