The study of metabolism is undergoing a renaissance. Since the year 2002, over 50
genetically-encoded fluorescent indicators (GEFIs) have been introduced, capable of …

Abstract Dual specificity phosphatase 1 (DUSP1) and valosin-containing protein (VCP) have
both been reported to regulate mitochondrial homeostasis. However, their impact on …

Valosin-containing protein (VCP/p97) is a member of the conserved type II AAA+ (ATPases
associated with diverse cellular activities) family of proteins with multiple biological …

Aims As heart failure (HF) progresses, ATP levels in myocardial cells decrease, and
myocardial contractility also decreases. Inotropic drugs improve myocardial contractility but …

Background Acute coronary syndrome (ACS) consists of a range of acute myocardial
ischemia-related manifestations. The adverse events of ACS are usually associated with …

Valosin-containing protein (VCP) is a member of AAA-ATPase superfamily involved in
various cellular functions. To investigate the pathophysiological role of VCP in metabolic …

Coronary heart disease (CHD) is a prevalent cardiac disease that causes over 370,000
deaths annually in the USA. In CHD, occlusion of a coronary artery causes ischemia of the …

Post-traumatic osteoarthritis (PTOA) is a major cause which hinders patients from the
recovery after intra-articular injuries or surgeries. Currently, no effective treatment is …

Acute myocardial infarction (AMI) leads to localized cardiac ischemia and can be fatal if
untreated. Despite being treatable, the threat of ischemia-reperfusion (IR) injury remains …

Acute kidney injury (AKI) is a life-threatening condition and often progresses to chronic
kidney disease or the development of other organ dysfunction even after recovery. Despite …