Challenges and opportunities for the next generation of cardiovascular tissue engineering
Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …
Cardiomyocyte maturation: new phase in development
Y Guo, WT Pu - Circulation research, 2020 - Am Heart Assoc
Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Biomedical research has relied on animal studies and conventional cell cultures for
decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that …
decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that …
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
The mammalian heart undergoes maturation during postnatal life to meet the increased
functional requirements of an adult. However, the key drivers of this process remain poorly …
functional requirements of an adult. However, the key drivers of this process remain poorly …
Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis
We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the
assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable …
assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable …
Measuring cell-generated forces: a guide to the available tools
WJ Polacheck, CS Chen - Nature methods, 2016 - nature.com
Forces generated by cells are critical regulators of cell adhesion, signaling, and function,
and they are also essential drivers in the morphogenetic events of development. Over the …
and they are also essential drivers in the morphogenetic events of development. Over the …
Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness
Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …
Organs-on-a-chip: a union of tissue engineering and microfabrication
We review the emergence of the new field of organ-on-a-chip (OOAC) engineering, from the
parent fields of tissue engineering and microfluidics. We place into perspective the tools and …
parent fields of tissue engineering and microfluidics. We place into perspective the tools and …
Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues
A Marsano, C Conficconi, M Lemme, P Occhetta… - Lab on a Chip, 2016 - pubs.rsc.org
In the past few years, microfluidic-based technology has developed microscale models
recapitulating key physical and biological cues typical of the native myocardium. However …
recapitulating key physical and biological cues typical of the native myocardium. However …