Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Osseointegration of implants is a complex physiological process that requires temporal and
spatial regulation of immune responses, angiogenesis, and osteogenesis. To achieve …

Rationale: The recent emergence of hydrogen sulfide (H2S) as a potent cardioprotective
signaling molecule necessitates the elucidation of its cytoprotective mechanisms. Objective …

Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting
cytokines and cytokine receptors with biologics has revolutionized the treatment of many of …

Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

Targeted therapeutics, particularly those that inhibit the activity of protein kinases that are
mutated and/or overexpressed in cancer, have revolutionized the treatment of some cancers …

Background Empagliflozin is a selective sodium–glucose cotransporter 2 (SGLT2) inhibitor
used to lower blood sugar in adults with type 2 diabetes. Empagliflozin also exerts …

Hydrogen sulfide (H2S) is a colorless, water soluble, flammable gas that has the
characteristic smell of rotten eggs. Like other members of the gasotransmitter family (nitric …

For more than a century, hydrogen sulfide (H2S) has been regarded as a toxic gas. This
review surveys the growing recognition of the role of H2S as an endogenous signaling …