Kinetoplast DNA is the mitochondrial DNA of trypanosomatid protozoa that cause diseases
in humans, livestock and plants. They consist of a complex network of interlocked DNA …

Kinetoplast DNA (kDNA) is the most structurally complex mitochondrial DNA in nature.
Unique to the single mitochondrion of unicellular ffagellates of the order Kinetoplastida …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

This book covers material that could be included in a one-quarter or one-semester course in
bioinorganic chemistry for graduate students and advanced undergraduate students in …

Abstract Poly (dA)· poly (dT) has unusual properties in that it cannot associate into
nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B …

Intrinsic bending of DNA molecules results from local structural polymorphism in regions of
homopolymeric dA· dT which are at least 4 base pairs long; the A· T tracts must be repeated …

The crystal structure of the trp repressor/operator complex shows an extensive contact
surface, including 24 direct and 6 solvent-mediated hydrogen bonds to the phosphate …

Publisher Summary This chapter discusses the detection and localization of single base
changes by denaturing gradient gel electrophoresis. For most purposes, single-stranded …

During the development of an organism different patterns of active genes are established in
the nuclei of differentiating cells. These specific gene patterns are translated into distinct …

The bending locus of trypanosome kinetoplast DNA, identified by gel electrophoresis, has
tracts of a simple repeat sequence (CA5–6 T) symmetrically distributed about it, with a …