Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …

Background Degenerative processes in neurodegenerative diseases can start years before
clinical manifestation. We aimed to establish whether a multiple sclerosis prodromal period …

Background and purpose Considerable functional reorganization takes place in
amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study …

The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …

Importance Hearing impairment (HI) in midlife (45-65 years of age) may be associated with
longitudinal neurodegeneration of temporal lobe structures, a biomarker of early Alzheimer …

We performed a systematic review of studies focusing on the automatic prediction of the
progression of mild cognitive impairment to Alzheimer's disease (AD) dementia, and a …

Developing and validating sensitive biomarkers for the presymptomatic stage of familial
frontotemporal dementia is an important step in early diagnosis and for the design of future …

Although hippocampal involvement in amyotrophic lateral sclerosis (ALS) has been
consistently highlighted by postmortem studies, memory impairment remains under …

Frontotemporal dementia (FTD) phenotypes have distinctive and well-established cortical
signatures, but their subcortical grey matter profiles are poorly characterised. The …