Abstract Purpose of Review Most drugs are given by the oral route. Oral intake allows direct
contact between the drug and the entire GI tract mucosa, exposing it to potential topical …

Capecitabine is an oral 5-fluorouracil prodrug with antimetabolite activity commonly used in
advanced colorectal and breast cancer. It presents with a generally good toxicity profile and …

Background The underlying mechanisms of chemotherapy-induced gastrointestinal (GI)
symptoms are poorly researched. This study characterised the nature, frequency, severity …

Cancer is one of the major problems for so many people around the world; therefore,
dedicating efforts to explore efficient therapeutic methodologies is very important for …

Background Capecitabine is a prodrug that is enzymatically converted to its active form,
fluorouracil (also called 5-fluorouracil), which is commonly used as adjuvant chemotherapy …

Capecitabine is an oral fluoropyrimidine used as adjuvant and palliative chemotherapy in
patients with colorectal cancer. Diarrhea is a well-known side effect of capecitabine and 5 …

Ileitis and colitis are known complications of capecitabine when used in patients with
gastrointestinal cancers. However, to our knowledge, pneumatosis intestinalis (PI) has not …

Capecitabine is a commonly used oral chemotherapeutic agent. Gastrointestinal (GI) side
effects are clinically well-known, however, the histopathologic changes have not been …

Capecitabine is a well-established agent for adjuvant chemotherapy in breast and colorectal
cancers. However, one of the limiting adverse events of this therapy is severe diarrhea …

We report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-
operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer …