Noncanonical Amino Acids in Biocatalysis

Z Birch-Price, FJ Hardy, TM Lister, AR Kohn… - Chemical …, 2024 - ACS Publications
In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

Molecular-modified photocathodes for applications in artificial photosynthesis and solar-to-fuel technologies

EA Reyes Cruz, D Nishiori, BL Wadsworth… - Chemical …, 2022 - ACS Publications
Nature offers inspiration for developing technologies that integrate the capture, conversion,
and storage of solar energy. In this review article, we highlight principles of natural …

Immobilized enzymes in biosensor applications

HH Nguyen, SH Lee, UJ Lee, CD Fermin, M Kim - Materials, 2019 - mdpi.com
Enzyme-based biosensing devices have been extensively developed over the last few
decades, and have proven to be innovative techniques in the qualitative and quantitative …

Designing logical codon reassignment–Expanding the chemistry in biology

A Dumas, L Lercher, CD Spicer, BG Davis - Chemical science, 2015 - pubs.rsc.org
Over the last decade, the ability to genetically encode unnatural amino acids (UAAs) has
evolved rapidly. The programmed incorporation of UAAs into recombinant proteins relies on …

Engineering pyrrolysine systems for genetic code expansion and reprogramming

DL Dunkelmann, JW Chin - Chemical Reviews, 2024 - ACS Publications
Over the past 16 years, genetic code expansion and reprogramming in living organisms has
been transformed by advances that leverage the unique properties of pyrrolysyl-tRNA …

Expanding the enzyme universe with genetically encoded unnatural amino acids

I Drienovská, G Roelfes - Nature Catalysis, 2020 - nature.com
The emergence of robust methods to expand the genetic code allows incorporation of non-
canonical amino acids into the polypeptide chain of proteins, thus making it possible to …

Catalysis and Electron Transfer in De Novo Designed Metalloproteins

KJ Koebke, TBJ Pinter, WC Pitts, VL Pecoraro - Chemical reviews, 2022 - ACS Publications
One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

From protein engineering to immobilization: promising strategies for the upgrade of industrial enzymes

RK Singh, MK Tiwari, R Singh, JK Lee - International journal of molecular …, 2013 - mdpi.com
Enzymes found in nature have been exploited in industry due to their inherent catalytic
properties in complex chemical processes under mild experimental and environmental …

Recent advances in biocatalysis with chemical modification and expanded amino acid alphabet

AD Pagar, MD Patil, DT Flood, TH Yoo… - Chemical …, 2021 - ACS Publications
The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

[HTML][HTML] Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications

B Wiltschi, T Cernava, A Dennig, MG Casas… - Biotechnology …, 2020 - Elsevier
Competitive sustainable production in industry demands new and better biocatalysts,
optimized bioprocesses and cost-effective product recovery. Our review sheds light on the …