ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies

AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

[HTML][HTML] Retinal biomarkers for Alzheimer disease: the facts and the future

A Yuan, CS Lee - Asia-Pacific Journal of Ophthalmology, 2022 - Elsevier
Alzheimer disease (AD) is a significant cause of morbidity and mortality worldwide, with
limited treatment options and considerable diagnostic challenges. Identification and …

Machine learning based on Optical Coherence Tomography images as a diagnostic tool for Alzheimer's disease

X Wang, B Jiao, H Liu, Y Wang, X Hao… - CNS Neuroscience …, 2022 - Wiley Online Library
Aims We mainly evaluate retinal alterations in Alzheimer's disease (AD) patients, investigate
the associations between retinal changes with AD biomarkers, and explore an optimal …

Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson's disease

CW Lin, TT Lai, SJ Chen, CH Lin - Geroscience, 2022 - Springer
The pathognomonic hallmark of Parkinson's disease (PD), α-synuclein, has been observed
in the retina of PD patients. We investigated whether biomarkers in the tears and retinal …

Beta-amyloid peptide in tears: an early diagnostic marker of Alzheimer's disease correlated with choroidal thickness

M Gharbiya, G Visioli, A Trebbastoni… - International Journal of …, 2023 - mdpi.com
We aimed to evaluate the diagnostic role of Alzheimer's disease (AD) biomarkers in tears as
well as their association with retinal and choroidal microstructures. In a cross-sectional …

Longitudinal analysis of the retina and choroid in cognitively normal individuals at higher genetic risk of Alzheimer disease

JP Ma, CB Robbins, JM Lee, S Soundararajan… - Ophthalmology …, 2022 - Elsevier
Purpose To assess the baseline differences and longitudinal rate of change in retinal and
choroidal imaging parameters between apolipoprotein ε4 (APOE ε4) carriers and …

A model eye for fluorescent characterization of retinal cultures and tissues

G Ferraro, Y Gigante, M Pitea, L Mautone, G Ruocco… - Scientific Reports, 2023 - nature.com
Many human neural or neurodegenerative diseases strongly affect the ocular and retinal
environment showing peculiar alterations which can be employed as specific disease …

Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans

F Abdolahi, V Yu, R Varma, X Zhou… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION We investigated whether retinal capillary perfusion is a biomarker of
cerebral small vessel disease and impaired cognition among Black Americans, an …

Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments

KL Nystuen, SM McNamee, M Akula, KM Holton… - Bioengineering, 2024 - mdpi.com
Alzheimer's Disease (AD) is a complex neurodegenerative disease resulting in progressive
loss of memory, language and motor abilities caused by cortical and hippocampal …

Hyperspectral retinal imaging in Alzheimer's disease and age-related macular degeneration: a review

X Du, J Park, R Zhao, RT Smith, Y Koronyo… - Acta Neuropathologica …, 2024 - Springer
While Alzheimer's disease and other neurodegenerative diseases have traditionally been
viewed as brain disorders, there is growing evidence indicating their manifestation in the …