ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
AC Raulin, SV Doss, ZA Trottier, TC Ikezu, G Bu… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
[HTML][HTML] Retinal biomarkers for Alzheimer disease: the facts and the future
A Yuan, CS Lee - Asia-Pacific Journal of Ophthalmology, 2022 - Elsevier
Alzheimer disease (AD) is a significant cause of morbidity and mortality worldwide, with
limited treatment options and considerable diagnostic challenges. Identification and …
limited treatment options and considerable diagnostic challenges. Identification and …
Machine learning based on Optical Coherence Tomography images as a diagnostic tool for Alzheimer's disease
X Wang, B Jiao, H Liu, Y Wang, X Hao… - CNS Neuroscience …, 2022 - Wiley Online Library
Aims We mainly evaluate retinal alterations in Alzheimer's disease (AD) patients, investigate
the associations between retinal changes with AD biomarkers, and explore an optimal …
the associations between retinal changes with AD biomarkers, and explore an optimal …
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson's disease
The pathognomonic hallmark of Parkinson's disease (PD), α-synuclein, has been observed
in the retina of PD patients. We investigated whether biomarkers in the tears and retinal …
in the retina of PD patients. We investigated whether biomarkers in the tears and retinal …
Beta-amyloid peptide in tears: an early diagnostic marker of Alzheimer's disease correlated with choroidal thickness
We aimed to evaluate the diagnostic role of Alzheimer's disease (AD) biomarkers in tears as
well as their association with retinal and choroidal microstructures. In a cross-sectional …
well as their association with retinal and choroidal microstructures. In a cross-sectional …
Longitudinal analysis of the retina and choroid in cognitively normal individuals at higher genetic risk of Alzheimer disease
JP Ma, CB Robbins, JM Lee, S Soundararajan… - Ophthalmology …, 2022 - Elsevier
Purpose To assess the baseline differences and longitudinal rate of change in retinal and
choroidal imaging parameters between apolipoprotein ε4 (APOE ε4) carriers and …
choroidal imaging parameters between apolipoprotein ε4 (APOE ε4) carriers and …
A model eye for fluorescent characterization of retinal cultures and tissues
Many human neural or neurodegenerative diseases strongly affect the ocular and retinal
environment showing peculiar alterations which can be employed as specific disease …
environment showing peculiar alterations which can be employed as specific disease …
Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans
F Abdolahi, V Yu, R Varma, X Zhou… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION We investigated whether retinal capillary perfusion is a biomarker of
cerebral small vessel disease and impaired cognition among Black Americans, an …
cerebral small vessel disease and impaired cognition among Black Americans, an …
Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treatments
KL Nystuen, SM McNamee, M Akula, KM Holton… - Bioengineering, 2024 - mdpi.com
Alzheimer's Disease (AD) is a complex neurodegenerative disease resulting in progressive
loss of memory, language and motor abilities caused by cortical and hippocampal …
loss of memory, language and motor abilities caused by cortical and hippocampal …
Hyperspectral retinal imaging in Alzheimer's disease and age-related macular degeneration: a review
While Alzheimer's disease and other neurodegenerative diseases have traditionally been
viewed as brain disorders, there is growing evidence indicating their manifestation in the …
viewed as brain disorders, there is growing evidence indicating their manifestation in the …