Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

Background Epithelial and endothelial barrier integrity, essential for homeostasis, is
maintained by cellular boarder structures known as tight junctions (TJs). In critical illness …

Background Septic shock is characterized by breakdown of the endothelial glycocalyx and
endothelial damage, contributing to fluid extravasation, organ failure and death. Albumin …

Sepsis is a heterogenous and highly complex clinical syndrome, which is caused by
infectious or noninfectious factors. Acute kidney injury (AKI) is one of the most common and …

Purpose The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill
patients remains an understudied area. Previous studies have identified that acute tubular …

The apelinergic pathway has been generating increasing interest in the past few years for its
potential as a therapeutic target in several conditions associated with the cardiovascular and …

Background Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the
major component of adherens junctions between endothelial cells. It is crucial for regulating …

Background The mechanisms driving acute kidney injury (AKI) in critically ill COVID-19
patients are unclear. We collected kidney biopsies from COVID-19 AKI patients within 30 …

Sepsis is a devastating clinical condition that can lead to multiple organ failure and death.
Despite advancements in our understanding of molecular mechanisms underlying sepsis …

Vascular endothelial permeability transition does not cause significant lesions, but
enhanced permeability may contribute to the development of vascular and other diseases …